Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

Tianke Wang, Liwei Zhang, Jie Wang, Yonghai Feng, Enquan Xu, Xiaobo Mao, Lei Liu

Research output: Contribution to journalArticle

Abstract

Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).

Original languageEnglish (US)
Pages (from-to)13084-13087
Number of pages4
JournalChemical Communications
Volume54
Issue number93
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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