Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to ‘mild cognitive impairment’ in adults with Down syndrome

The Alzheimer’s Disease in Down Syndrome (ADDS) Consortium

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample of 185 adults with Down syndrome (DS), emphasizing ‘mild cognitive impairment (MCI-DS)’. Method: Knowledgeable informants were interviewed with the NTG-EDSD, and findings were compared to an independent dementia status rating based on consensus review of detailed assessments of cognition, functional abilities and health status (including physician examination). Results: Results indicated that sections of the NTG-EDSD were sensitive to MCI-DS, with one or more concerns within the ‘Memory’ or ‘Language and Communication’ domains being most informative. Conclusions: The NTG-EDSD is a useful tool for evaluating dementia status, including MCI-DS. However, estimates of sensitivity and specificity, even for detecting frank dementia, indicated that NTG-EDSD findings need to be supplemented by additional sources of relevant information to achieve an acceptable level of diagnostic/screening accuracy.

Original languageEnglish (US)
Pages (from-to)905-915
Number of pages11
JournalJournal of Applied Research in Intellectual Disabilities
Volume34
Issue number3
DOIs
StatePublished - May 2021

Keywords

  • Alzheimer's disease
  • NTG-EDSD
  • dementia
  • down syndrome
  • mild cognitive impairment

ASJC Scopus subject areas

  • Education
  • Developmental and Educational Psychology

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