Avaliação do metabolismo dos fosfatos de alta energia em pacientes com doença de Chagas

Translated title of the contribution: Evaluation of the metabolism of high energy phosphates in patients with Chagas' disease

Ana Maria Betim Paes Leme, Vera Maria Cury Salemi, José Rodrigues Parga, Bárbara Maria Ianni, Charles Mady, Robert G. Weiss, Roberto Kalil-Filho

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Abnormalities in myocardial metabolism have been observed in patients with heart failure of different etiologies. Magnetic resonance spectroscopy (MRS) with phosphorus-31 is a noninvasive technique that allows detection of myocardial metabolic changes. Objective: To determine the resting metabolism of high-energy phosphates in patients with Chagas' disease (CD) by MRS with phosphorus-31. Methods: We studied 39 patients with CD, 23 with preserved ventricular function (PF Group) and 16 with ventricular dysfunction (VD Group), assessed by Doppler echocardiography. MRS of the anterosseptal region was performed in 39 patients and 8 normal subjects (C Group) through a Phillips 1.5 Tesla device, obtaining the phosphocreatine/beta-adenosine triphosphate myocardial ratio (PCr/β-ATP). Results: The levels of cardiac PCr/β-ATP were reduced in VD Group in relation to PF Group, and the latter presented reduced levels compared to C Group (VD Group: 0.89 ± 0.31 vs PF Group: 1.47 ± 0.34 vs C Group: 1.88 ± 0.08, p < 0.001). A correlation was found between left ventricular ejection fraction and PCr/β-ATP in 39 patients (r = 0.64, p <0.001). Patients under functional class I (n = 22) presented PCr/β-ATP of 1.45 ± 0.35, and those in functional classes II and III (n = 17), PCr/β-ATP of 0.94 ± 0.36 (p < 0.001). Conclusion: The 31-phosphorus MRS was able to detect non-invasively changes in the rest energy metabolism of patients with Chagas' disease, with and without systolic dysfunction. These changes were related to the severity of heart impairment.

Translated title of the contributionEvaluation of the metabolism of high energy phosphates in patients with Chagas' disease
Original languagePortuguese
Pages (from-to)264-271
Number of pages8
JournalArquivos brasileiros de cardiologia
Volume95
Issue number2
DOIs
StatePublished - Aug 2010

Keywords

  • Chagas cardiomyopathy
  • Chagas' disease
  • Energy metabolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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