Evaluation of the effectiveness of oral beta-blockade in patients for coronary computed tomographic angiography

Harpreet K. Pannu, Charlotte Sullivan, Shenghan Lai, Elliot K Fishman

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine the effectiveness of oral medications in lowering the resting heart rate (HR) for coronary computed tomographic angiography (CTA). BACKGROUND: The protocol of premedication for cardiac CTA is variable in terms of type, dose, route, and timing of administration. METHODS: Nursing records were retrospectively reviewed in 238 consecutive patients having coronary CTA and 217 patients evaluated for type and amount of oral medication administered. The HR on arrival to computed tomography (CT) and 30 and 60 minutes after medication was noted. RESULTS: One hundred twenty-three patients (56.6%) had a mean HR of 78.3 ± 9.4 beats per minute (bpm) on arrival and were given medication. One hundred fourteen patients (92.6%) were given 50 mg of oral metoprolol, with the remaining receiving 25 to 100 mg and 1 patient receiving 30 mg of oral diltiazem. Sixty-eight patients (55.2%) were monitored for less than 1 hour and had a mean HR of 73.1 ± 5.1 bpm on arrival, a 9.8 ± 4.7-bpm decrease in HR at 30 minutes, and an HR of 56.5 ± 7.2 bpm during CT. Thirty-nine patients (31.7%) had a mean HR of 81.3 ± 7.2 bpm on arrival, a 9.8 ± 7.4-bpm decrease in HR at 30 minutes, a 16.9 ± 6.3-bpm decrease in HR at 60 minutes, and an HR of 59.8 ± 4.8 bpm during CT. Sixteen patients were monitored for more than 1 hour, followed by intravenous metoprolol. These patients had a baseline HR of 93.5 ± 8.9 bpm, a 13.1 ± 6.4-bpm decrease in HR at 30 minutes, a 15.9 ± 6.8-bpm decrease in HR at 60 minutes, and an HR of 68.1 ± 7.9 bpm during CT. There were no complications due to metoprolol. CONCLUSION: Oral metoprolol given 1 hour before cardiac CT effectively and safely lowers the resting HR in most patients.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume32
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

Angiography
Heart Rate
Metoprolol
Tomography
Nursing Records
Premedication
Diltiazem

Keywords

  • Beta-blocker
  • Coronary CT angiography
  • Heart rate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Evaluation of the effectiveness of oral beta-blockade in patients for coronary computed tomographic angiography. / Pannu, Harpreet K.; Sullivan, Charlotte; Lai, Shenghan; Fishman, Elliot K.

In: Journal of Computer Assisted Tomography, Vol. 32, No. 2, 03.2008, p. 247-251.

Research output: Contribution to journalArticle

@article{d787d10cf74146238cf9e53a5c898fae,
title = "Evaluation of the effectiveness of oral beta-blockade in patients for coronary computed tomographic angiography",
abstract = "OBJECTIVE: To determine the effectiveness of oral medications in lowering the resting heart rate (HR) for coronary computed tomographic angiography (CTA). BACKGROUND: The protocol of premedication for cardiac CTA is variable in terms of type, dose, route, and timing of administration. METHODS: Nursing records were retrospectively reviewed in 238 consecutive patients having coronary CTA and 217 patients evaluated for type and amount of oral medication administered. The HR on arrival to computed tomography (CT) and 30 and 60 minutes after medication was noted. RESULTS: One hundred twenty-three patients (56.6{\%}) had a mean HR of 78.3 ± 9.4 beats per minute (bpm) on arrival and were given medication. One hundred fourteen patients (92.6{\%}) were given 50 mg of oral metoprolol, with the remaining receiving 25 to 100 mg and 1 patient receiving 30 mg of oral diltiazem. Sixty-eight patients (55.2{\%}) were monitored for less than 1 hour and had a mean HR of 73.1 ± 5.1 bpm on arrival, a 9.8 ± 4.7-bpm decrease in HR at 30 minutes, and an HR of 56.5 ± 7.2 bpm during CT. Thirty-nine patients (31.7{\%}) had a mean HR of 81.3 ± 7.2 bpm on arrival, a 9.8 ± 7.4-bpm decrease in HR at 30 minutes, a 16.9 ± 6.3-bpm decrease in HR at 60 minutes, and an HR of 59.8 ± 4.8 bpm during CT. Sixteen patients were monitored for more than 1 hour, followed by intravenous metoprolol. These patients had a baseline HR of 93.5 ± 8.9 bpm, a 13.1 ± 6.4-bpm decrease in HR at 30 minutes, a 15.9 ± 6.8-bpm decrease in HR at 60 minutes, and an HR of 68.1 ± 7.9 bpm during CT. There were no complications due to metoprolol. CONCLUSION: Oral metoprolol given 1 hour before cardiac CT effectively and safely lowers the resting HR in most patients.",
keywords = "Beta-blocker, Coronary CT angiography, Heart rate",
author = "Pannu, {Harpreet K.} and Charlotte Sullivan and Shenghan Lai and Fishman, {Elliot K}",
year = "2008",
month = "3",
doi = "10.1097/RCT.0b013e318075e759",
language = "English (US)",
volume = "32",
pages = "247--251",
journal = "Journal of Computer Assisted Tomography",
issn = "0363-8715",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Evaluation of the effectiveness of oral beta-blockade in patients for coronary computed tomographic angiography

AU - Pannu, Harpreet K.

AU - Sullivan, Charlotte

AU - Lai, Shenghan

AU - Fishman, Elliot K

PY - 2008/3

Y1 - 2008/3

N2 - OBJECTIVE: To determine the effectiveness of oral medications in lowering the resting heart rate (HR) for coronary computed tomographic angiography (CTA). BACKGROUND: The protocol of premedication for cardiac CTA is variable in terms of type, dose, route, and timing of administration. METHODS: Nursing records were retrospectively reviewed in 238 consecutive patients having coronary CTA and 217 patients evaluated for type and amount of oral medication administered. The HR on arrival to computed tomography (CT) and 30 and 60 minutes after medication was noted. RESULTS: One hundred twenty-three patients (56.6%) had a mean HR of 78.3 ± 9.4 beats per minute (bpm) on arrival and were given medication. One hundred fourteen patients (92.6%) were given 50 mg of oral metoprolol, with the remaining receiving 25 to 100 mg and 1 patient receiving 30 mg of oral diltiazem. Sixty-eight patients (55.2%) were monitored for less than 1 hour and had a mean HR of 73.1 ± 5.1 bpm on arrival, a 9.8 ± 4.7-bpm decrease in HR at 30 minutes, and an HR of 56.5 ± 7.2 bpm during CT. Thirty-nine patients (31.7%) had a mean HR of 81.3 ± 7.2 bpm on arrival, a 9.8 ± 7.4-bpm decrease in HR at 30 minutes, a 16.9 ± 6.3-bpm decrease in HR at 60 minutes, and an HR of 59.8 ± 4.8 bpm during CT. Sixteen patients were monitored for more than 1 hour, followed by intravenous metoprolol. These patients had a baseline HR of 93.5 ± 8.9 bpm, a 13.1 ± 6.4-bpm decrease in HR at 30 minutes, a 15.9 ± 6.8-bpm decrease in HR at 60 minutes, and an HR of 68.1 ± 7.9 bpm during CT. There were no complications due to metoprolol. CONCLUSION: Oral metoprolol given 1 hour before cardiac CT effectively and safely lowers the resting HR in most patients.

AB - OBJECTIVE: To determine the effectiveness of oral medications in lowering the resting heart rate (HR) for coronary computed tomographic angiography (CTA). BACKGROUND: The protocol of premedication for cardiac CTA is variable in terms of type, dose, route, and timing of administration. METHODS: Nursing records were retrospectively reviewed in 238 consecutive patients having coronary CTA and 217 patients evaluated for type and amount of oral medication administered. The HR on arrival to computed tomography (CT) and 30 and 60 minutes after medication was noted. RESULTS: One hundred twenty-three patients (56.6%) had a mean HR of 78.3 ± 9.4 beats per minute (bpm) on arrival and were given medication. One hundred fourteen patients (92.6%) were given 50 mg of oral metoprolol, with the remaining receiving 25 to 100 mg and 1 patient receiving 30 mg of oral diltiazem. Sixty-eight patients (55.2%) were monitored for less than 1 hour and had a mean HR of 73.1 ± 5.1 bpm on arrival, a 9.8 ± 4.7-bpm decrease in HR at 30 minutes, and an HR of 56.5 ± 7.2 bpm during CT. Thirty-nine patients (31.7%) had a mean HR of 81.3 ± 7.2 bpm on arrival, a 9.8 ± 7.4-bpm decrease in HR at 30 minutes, a 16.9 ± 6.3-bpm decrease in HR at 60 minutes, and an HR of 59.8 ± 4.8 bpm during CT. Sixteen patients were monitored for more than 1 hour, followed by intravenous metoprolol. These patients had a baseline HR of 93.5 ± 8.9 bpm, a 13.1 ± 6.4-bpm decrease in HR at 30 minutes, a 15.9 ± 6.8-bpm decrease in HR at 60 minutes, and an HR of 68.1 ± 7.9 bpm during CT. There were no complications due to metoprolol. CONCLUSION: Oral metoprolol given 1 hour before cardiac CT effectively and safely lowers the resting HR in most patients.

KW - Beta-blocker

KW - Coronary CT angiography

KW - Heart rate

UR - http://www.scopus.com/inward/record.url?scp=41749085541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41749085541&partnerID=8YFLogxK

U2 - 10.1097/RCT.0b013e318075e759

DO - 10.1097/RCT.0b013e318075e759

M3 - Article

VL - 32

SP - 247

EP - 251

JO - Journal of Computer Assisted Tomography

JF - Journal of Computer Assisted Tomography

SN - 0363-8715

IS - 2

ER -