Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications

Marcia W. Patchan, J. Jeremy Chae, Justin D. Lee, Xiomara Calderon-Colon, Jeffrey P. Maranchi, Russell L. McCally, Oliver D Schein, Jennifer Hartt Elisseeff, Morgana M. Trexler

Research output: Contribution to journalArticle

Abstract

Prompt emergency treatment for ocular injury, particularly in a battlefield setting, is essential to preserve vision, reduce pain, and prevent secondary infection. A bandage contact lens that could be applied in the field, at the time of injury, would protect the injured ocular surface until hospital treatment is available. Cellulose, a natural polymer, is widely used in biomedical applications including bandage materials. Hydrogels synthesized from different cellulose sources, such as plants, cotton, and bacteria, can have the optical transparency and mechanical strength of contact lenses, by tailoring synthesis parameters. Thus, we optimized the fabrication of cellulose-based hydrogels and evaluated their in vivo biocompatibility and related physical properties. Our data demonstrate that along with tailorable physical properties, our novel cellulose-based hydrogels could be made with contact lens geometry, exhibit no significant signs of material toxicity after 22 days of in vivo testing, and show significant promise for use as a corneal bandage immediately following ocular trauma.

Original languageEnglish (US)
Pages (from-to)1049-1059
Number of pages11
JournalJournal of Biomaterials Applications
Volume30
Issue number7
DOIs
StatePublished - Feb 1 2016

Fingerprint

Hydrogels
Contact lenses
Biocompatibility
Cellulose
Transparency
Physical properties
Natural polymers
Cotton
Strength of materials
Toxicity
Bacteria
Fabrication
Geometry
Testing

Keywords

  • bandage contact lens
  • biocompatibility
  • Cellulose
  • hydrogel
  • ocular injury

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Patchan, M. W., Chae, J. J., Lee, J. D., Calderon-Colon, X., Maranchi, J. P., McCally, R. L., ... Trexler, M. M. (2016). Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications. Journal of Biomaterials Applications, 30(7), 1049-1059. https://doi.org/10.1177/0885328215616273

Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications. / Patchan, Marcia W.; Chae, J. Jeremy; Lee, Justin D.; Calderon-Colon, Xiomara; Maranchi, Jeffrey P.; McCally, Russell L.; Schein, Oliver D; Elisseeff, Jennifer Hartt; Trexler, Morgana M.

In: Journal of Biomaterials Applications, Vol. 30, No. 7, 01.02.2016, p. 1049-1059.

Research output: Contribution to journalArticle

Patchan, Marcia W. ; Chae, J. Jeremy ; Lee, Justin D. ; Calderon-Colon, Xiomara ; Maranchi, Jeffrey P. ; McCally, Russell L. ; Schein, Oliver D ; Elisseeff, Jennifer Hartt ; Trexler, Morgana M. / Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications. In: Journal of Biomaterials Applications. 2016 ; Vol. 30, No. 7. pp. 1049-1059.
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