Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications

Marcia W. Patchan, J. Jeremy Chae, Justin D. Lee, Xiomara Calderon-Colon, Jeffrey P. Maranchi, Russell L. McCally, Oliver D. Schein, Jennifer H. Elisseeff, Morgana M. Trexler

Research output: Contribution to journalArticle

Abstract

Prompt emergency treatment for ocular injury, particularly in a battlefield setting, is essential to preserve vision, reduce pain, and prevent secondary infection. A bandage contact lens that could be applied in the field, at the time of injury, would protect the injured ocular surface until hospital treatment is available. Cellulose, a natural polymer, is widely used in biomedical applications including bandage materials. Hydrogels synthesized from different cellulose sources, such as plants, cotton, and bacteria, can have the optical transparency and mechanical strength of contact lenses, by tailoring synthesis parameters. Thus, we optimized the fabrication of cellulose-based hydrogels and evaluated their in vivo biocompatibility and related physical properties. Our data demonstrate that along with tailorable physical properties, our novel cellulose-based hydrogels could be made with contact lens geometry, exhibit no significant signs of material toxicity after 22 days of in vivo testing, and show significant promise for use as a corneal bandage immediately following ocular trauma.

Original languageEnglish (US)
Pages (from-to)1049-1059
Number of pages11
JournalJournal of Biomaterials Applications
Volume30
Issue number7
DOIs
StatePublished - Feb 1 2016

Keywords

  • Cellulose
  • bandage contact lens
  • biocompatibility
  • hydrogel
  • ocular injury

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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