Evaluation of the association between arsenic and diabetes

A National Toxicology Program workshop review

Elizabeth A. Maull, Habibul Ahsan, Joshua Edwards, Matthew P. Longnecker, Ana Navas Acien, Jingbo Pi, Ellen Silbergeld, Miroslav Styblo, Chin Hsiao Tseng, Kristina A. Thayer, Dana Loomis

Research output: Contribution to journalArticle

Abstract

Background: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase >50% in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This review is derived from discussions at that workshop. Objectives: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome. Data Sources, Extraction, and Synthesis: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles. Conclusions: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (≥150μg arsenic/L in drinking water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (

Original languageEnglish (US)
Pages (from-to)1658-1670
Number of pages13
JournalEnvironmental Health Perspectives
Volume120
Issue number12
DOIs
StatePublished - 2012

Fingerprint

Arsenic
Toxicology
Education
Obesity
Inorganic Chemicals
Literature
Environmental Health
Information Storage and Retrieval
PubMed
Drinking Water
Research
Population

Keywords

  • Animal
  • Arsenic toxicity
  • Cell line
  • Chemically induced/epidemiology
  • Cultured cell
  • Diabetes
  • Environmental epidemiology
  • Glucose
  • Insulin
  • Metabolism
  • Obesity

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Maull, E. A., Ahsan, H., Edwards, J., Longnecker, M. P., Navas Acien, A., Pi, J., ... Loomis, D. (2012). Evaluation of the association between arsenic and diabetes: A National Toxicology Program workshop review. Environmental Health Perspectives, 120(12), 1658-1670. https://doi.org/10.1289/ehp.1104579

Evaluation of the association between arsenic and diabetes : A National Toxicology Program workshop review. / Maull, Elizabeth A.; Ahsan, Habibul; Edwards, Joshua; Longnecker, Matthew P.; Navas Acien, Ana; Pi, Jingbo; Silbergeld, Ellen; Styblo, Miroslav; Tseng, Chin Hsiao; Thayer, Kristina A.; Loomis, Dana.

In: Environmental Health Perspectives, Vol. 120, No. 12, 2012, p. 1658-1670.

Research output: Contribution to journalArticle

Maull, EA, Ahsan, H, Edwards, J, Longnecker, MP, Navas Acien, A, Pi, J, Silbergeld, E, Styblo, M, Tseng, CH, Thayer, KA & Loomis, D 2012, 'Evaluation of the association between arsenic and diabetes: A National Toxicology Program workshop review', Environmental Health Perspectives, vol. 120, no. 12, pp. 1658-1670. https://doi.org/10.1289/ehp.1104579
Maull, Elizabeth A. ; Ahsan, Habibul ; Edwards, Joshua ; Longnecker, Matthew P. ; Navas Acien, Ana ; Pi, Jingbo ; Silbergeld, Ellen ; Styblo, Miroslav ; Tseng, Chin Hsiao ; Thayer, Kristina A. ; Loomis, Dana. / Evaluation of the association between arsenic and diabetes : A National Toxicology Program workshop review. In: Environmental Health Perspectives. 2012 ; Vol. 120, No. 12. pp. 1658-1670.
@article{9f31ae441ccb44bda55f949182b83742,
title = "Evaluation of the association between arsenic and diabetes: A National Toxicology Program workshop review",
abstract = "Background: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase >50{\%} in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This review is derived from discussions at that workshop. Objectives: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome. Data Sources, Extraction, and Synthesis: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles. Conclusions: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (≥150μg arsenic/L in drinking water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (",
keywords = "Animal, Arsenic toxicity, Cell line, Chemically induced/epidemiology, Cultured cell, Diabetes, Environmental epidemiology, Glucose, Insulin, Metabolism, Obesity",
author = "Maull, {Elizabeth A.} and Habibul Ahsan and Joshua Edwards and Longnecker, {Matthew P.} and {Navas Acien}, Ana and Jingbo Pi and Ellen Silbergeld and Miroslav Styblo and Tseng, {Chin Hsiao} and Thayer, {Kristina A.} and Dana Loomis",
year = "2012",
doi = "10.1289/ehp.1104579",
language = "English (US)",
volume = "120",
pages = "1658--1670",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "12",

}

TY - JOUR

T1 - Evaluation of the association between arsenic and diabetes

T2 - A National Toxicology Program workshop review

AU - Maull, Elizabeth A.

AU - Ahsan, Habibul

AU - Edwards, Joshua

AU - Longnecker, Matthew P.

AU - Navas Acien, Ana

AU - Pi, Jingbo

AU - Silbergeld, Ellen

AU - Styblo, Miroslav

AU - Tseng, Chin Hsiao

AU - Thayer, Kristina A.

AU - Loomis, Dana

PY - 2012

Y1 - 2012

N2 - Background: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase >50% in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This review is derived from discussions at that workshop. Objectives: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome. Data Sources, Extraction, and Synthesis: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles. Conclusions: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (≥150μg arsenic/L in drinking water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (

AB - Background: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase >50% in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This review is derived from discussions at that workshop. Objectives: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome. Data Sources, Extraction, and Synthesis: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles. Conclusions: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (≥150μg arsenic/L in drinking water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (

KW - Animal

KW - Arsenic toxicity

KW - Cell line

KW - Chemically induced/epidemiology

KW - Cultured cell

KW - Diabetes

KW - Environmental epidemiology

KW - Glucose

KW - Insulin

KW - Metabolism

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84864884168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864884168&partnerID=8YFLogxK

U2 - 10.1289/ehp.1104579

DO - 10.1289/ehp.1104579

M3 - Article

VL - 120

SP - 1658

EP - 1670

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 12

ER -