Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori

Xavier Haristoy, Jed W. Fahey, Isabelle Scholtus, Alain Lozniewski

Research output: Contribution to journalArticle

Abstract

The antibacterial activity of sulforaphane [4-(methylsulfinyl)butyl isothiocyanate] has been previously described. We have analysed the activities of 12 isothiocyanates (ITC) including sulphoraphane on 25 strains of Helicobacter pylori using an agar dilution assay. In addition, bactericidal effects against H. pylon were determined for the 6 most active ITCs, both directly and against intracellular bacteria in cultured human epithelial (HEp-2) cells. The MIC90 values for these ITCs ranged between 4 and 32 μg/mL and four of the most potent compounds exhibited bactericidal activity against both extra- and intracellular bacteria. Overall, our data indicate that ITCs have a potent antibacterial effect against H. pylori and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. pylori eradication.

Original languageEnglish (US)
Pages (from-to)326-330
Number of pages5
JournalPlanta Medica
Volume71
Issue number4
DOIs
StatePublished - May 27 2005

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Keywords

  • Helicobacter pylon
  • Isothiocyanate
  • Minimal inhibitory concentration
  • Time-to-kill assay

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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