Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging

Henrique T. Moreira, Gustavo J. Volpe, José A. Marin-Neto, Bharath Ambale Venkatesh, Chike C. Nwabuo, Henrique S. Trad, Minna M D Romano, Antonio Pazin-Filho, Benedito C. MacIel, Joao Lima, André Schmidt

Research output: Contribution to journalArticle

Abstract

Background-Right ventricular (RV) impairment is postulated to be responsible for prominent systemic congestion in Chagas disease. However, occurrence of primary RV dysfunction in Chagas disease remains controversial. We aimed to study RV systolic function in patients with Chagas disease using cardiac magnetic resonance. Methods and Results-This cross-sectional study included 158 individuals with chronic Chagas disease who underwent cardiac magnetic resonance. RV systolic dysfunction was defined as reduced RV ejection fraction based on predefined cutoffs accounting for age and sex. Multivariable logistic regression was used to verify the relationship of RV systolic dysfunction with age, sex, functional class, use of medications for heart failure, atrial fibrillation, and left ventricular systolic dysfunction. Mean age was 54±13 years, 51.2% men. RV systolic dysfunction was identified in 58 (37%) individuals. Although usually associated with reduced left ventricular ejection fraction, isolated RV systolic dysfunction was found in 7 (4.4%) patients, 2 of them in early stages of Chagas disease. Presence of RV dysfunction was not significantly different in patients with indeterminate/digestive form of Chagas disease (35.7%) compared with those with Chagas cardiomyopathy (36.8%) (P=1.000). Conclusions-In chronic Chagas disease, RV systolic dysfunction is more commonly associated with left ventricular systolic dysfunction, although isolated and early RV dysfunction can also be identified.

Original languageEnglish (US)
Article numbere005571
JournalCirculation: Cardiovascular Imaging
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2017

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Right Ventricular Dysfunction
Right Ventricular Function
Chagas Disease
Magnetic Resonance Imaging
Left Ventricular Dysfunction
Stroke Volume
Chagas Cardiomyopathy
Chronic Disease
Magnetic Resonance Spectroscopy
Atrial Fibrillation
Heart Failure
Cross-Sectional Studies
Logistic Models

Keywords

  • Atrial fibrillation
  • Chagas cardiomyopathy
  • Heart failure
  • Magnetic resonance imaging
  • Systole

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging. / Moreira, Henrique T.; Volpe, Gustavo J.; Marin-Neto, José A.; Ambale Venkatesh, Bharath; Nwabuo, Chike C.; Trad, Henrique S.; Romano, Minna M D; Pazin-Filho, Antonio; MacIel, Benedito C.; Lima, Joao; Schmidt, André.

In: Circulation: Cardiovascular Imaging, Vol. 10, No. 3, e005571, 01.03.2017.

Research output: Contribution to journalArticle

Moreira, HT, Volpe, GJ, Marin-Neto, JA, Ambale Venkatesh, B, Nwabuo, CC, Trad, HS, Romano, MMD, Pazin-Filho, A, MacIel, BC, Lima, J & Schmidt, A 2017, 'Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging', Circulation: Cardiovascular Imaging, vol. 10, no. 3, e005571. https://doi.org/10.1161/CIRCIMAGING.116.005571
Moreira, Henrique T. ; Volpe, Gustavo J. ; Marin-Neto, José A. ; Ambale Venkatesh, Bharath ; Nwabuo, Chike C. ; Trad, Henrique S. ; Romano, Minna M D ; Pazin-Filho, Antonio ; MacIel, Benedito C. ; Lima, Joao ; Schmidt, André. / Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging. In: Circulation: Cardiovascular Imaging. 2017 ; Vol. 10, No. 3.
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