Evaluation of proposed staging systems for human papillomavirus-related oropharyngeal squamous cell carcinoma

Ian James Malm, Caleb J. Fan, Linda X. Yin, David X. Li, Wayne M. Koch, Christine G. Gourin, Karen T. Pitman, Jeremy D. Richmon, William H. Westra, Hyunseok Kang, Harry Quon, David W. Eisele, Carole Fakhry

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-positive OPC. The purpose of the current study was to validate and compare 2 recently proposed staging systems for HPV-positive OPC. METHODS: Patients treated for HPV-positive OPC from 2005 to 2015 at Johns Hopkins Hospital (JHH) were included for analysis. The International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S) and The University of Texas MD Anderson Cancer Center (MDACC) staging systems were applied and survival was calculated using Kaplan-Meier methods. Cox proportional hazard regression was used to determine the relationship between stage of disease and survival. Models were compared using the Akaike information criterion (AIC). RESULTS: A total of 435 patients were eligible for analysis. There was a dramatic shift in lymph node category and overall stage of disease when ICON-S and MDACC stage were applied to the JHH cohort. There was superior stratification of overall survival and progression-free survival by ICON-S stage. Both proposed models had an improved fit based on AIC scores (P<.001 for both) over the AJCC-7ed. The ICON-S staging system had the lowest AIC score, and thus a better fit within the JHH population. CONCLUSIONS: The current analysis provides external validation for both staging systems in an independent and heterogeneously treated patient population. Although the MDACC staging system is an improvement over the AJCC-7ed, the ICON-S stage provides superior stratification of overall and progression-free survival, thereby supporting its use as the updated AJCC staging system for OPC. Cancer 2017;123:1768–1777.

Original languageEnglish (US)
Pages (from-to)1768-1777
Number of pages10
JournalCancer
Volume123
Issue number10
DOIs
StatePublished - May 15 2017

Keywords

  • TNM stage
  • human papillomavirus
  • oropharyngeal cancer
  • squamous cell carcinoma
  • survival analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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