Evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models

F. C. Odds, F. Van Gerven, A. Espinel-Ingroff, M. S. Bartlett, M. A. Ghannoum, M. V. Lancaster, M. A. Pfaller, J. H. Rex, M. G. Rinaldi, T. J. Walsh

Research output: Contribution to journalArticle

Abstract

Nine isolates of filamentous fungi previously tested in 11 different laboratories for their susceptibilities to amphotericin B and itraconazole in vitro were injected intravenously into mice and guinea pigs, and responses to treatment with both agents were studied. The experiments were done in a single laboratory. Mean survival times, the percentages of animals surviving 12 days after infection, and culture results for samples of deep organs obtained postmortem were used as markers of antifungal efficacy. Because of variations in organism pathogenicity, interpretable test systems in vivo could not be established for Fusarium spp. in mice or guinea pigs or for Pseudallescheria boydii in mice, even with the use of immunosuppressive pretreatments. Among the infections that could be evaluated, some degree of response to the corresponding treatment in vivo was seen in animals infected with each of two Rhizopus arrhizus isolates susceptible to amphotericin B at

Original languageEnglish (US)
Pages (from-to)282-288
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number2
StatePublished - Feb 1998
Externally publishedYes

Fingerprint

Fungi
Animal Models
Amphotericin B
Guinea Pigs
Pseudallescheria
Infection
Rhizopus
Itraconazole
Fusarium
Immunosuppressive Agents
Virulence
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Odds, F. C., Van Gerven, F., Espinel-Ingroff, A., Bartlett, M. S., Ghannoum, M. A., Lancaster, M. V., ... Walsh, T. J. (1998). Evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models. Antimicrobial Agents and Chemotherapy, 42(2), 282-288.

Evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models. / Odds, F. C.; Van Gerven, F.; Espinel-Ingroff, A.; Bartlett, M. S.; Ghannoum, M. A.; Lancaster, M. V.; Pfaller, M. A.; Rex, J. H.; Rinaldi, M. G.; Walsh, T. J.

In: Antimicrobial Agents and Chemotherapy, Vol. 42, No. 2, 02.1998, p. 282-288.

Research output: Contribution to journalArticle

Odds, FC, Van Gerven, F, Espinel-Ingroff, A, Bartlett, MS, Ghannoum, MA, Lancaster, MV, Pfaller, MA, Rex, JH, Rinaldi, MG & Walsh, TJ 1998, 'Evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models', Antimicrobial Agents and Chemotherapy, vol. 42, no. 2, pp. 282-288.
Odds, F. C. ; Van Gerven, F. ; Espinel-Ingroff, A. ; Bartlett, M. S. ; Ghannoum, M. A. ; Lancaster, M. V. ; Pfaller, M. A. ; Rex, J. H. ; Rinaldi, M. G. ; Walsh, T. J. / Evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models. In: Antimicrobial Agents and Chemotherapy. 1998 ; Vol. 42, No. 2. pp. 282-288.
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