Evaluation of Peritumoral Fibrosis in Metastatic Colorectal Adenocarcinoma to the Liver Using Digital Image Analysis

Kevin M. Waters, Tricia R. Cottrell, Sepideh Besharati, Qingfeng Zhu, Robert A. Anders

Research output: Contribution to journalArticle

Abstract

Objectives It is challenging to separate peritumoral fibrosis from fibrosis due to chronic liver disease in mass-directed liver biopsies. We evaluated the distance that peritumoral fibrosis extends from metastatic colorectal adenocarcinoma in liver. Methods Peritumoral and distant uninvolved liver trichrome stains from 25 cases were analyzed using digital image analysis. Fibrosis was quantitated at concentric intervals from each tumor and in uninvolved liver. Results There was a 3.9 fold (range 0.9-18.6) median increase in fibrosis in the first 0.5 mm of peritumoral liver compared to distant liver. Fibrosis levels returned to baseline at median 2.5 mm (interquartile range 1.5-5.0 mm) from tumor. Conclusions Fibrosis is markedly increased in peritumoral liver. Fibrosis levels returned to baseline by 5 mm from tumor in approximately 75% of cases. Pathologists should be cautious of fibrosis in mass-directed liver biopsies without at least 5 mm of liver tissue distal to the mass.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalAmerican journal of clinical pathology
Volume151
Issue number2
DOIs
StatePublished - Jan 7 2019

Keywords

  • Digital image analysis
  • Fibrosis
  • Liver
  • Metastatic carcinoma
  • Peritumoral fibrosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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