Abstract
Objective: Standardized case definitions have recently been proposed by the International Network for the Study of HIV-associated immune reconstitution inflammatory syndrome (INSHI; [IRIS]) for use in resource-limited settings. We evaluated paradoxical tuberculosis (TB)-associated IRIS in a large cohort from a TB endemic setting with the use of these case definitions. Design: A retrospective cohort study. Method: We reviewed records from 1250 South African patients who initiated antiretroviral therapy (ART) over a 5-year period. Results: A total of 333 (27%) of the patients in the cohort had prevalent TB at the initiation of ART. Of 54 possible paradoxical TB-associated IRIS cases, 35 fulfilled the INSHI case definitions (11% of TB cases). Conclusions: INSHI-standardized case definitions were used successfully in identifying paradoxical TB-associated IRIS in this cohort and resulted in a similar proportion of TB IRIS cases ( %) as that reported in previous studies from resource-limited settings (8%-l3%). This case definition should be evaluated prospectively.
Original language | English (US) |
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Pages (from-to) | 104-108 |
Number of pages | 5 |
Journal | Journal of the International Association of Physicians in AIDS Care |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Mar 2010 |
Keywords
- HIV
- INSHI
- Immune reconstitution
- Resource-limited settings
- Tuberculosis
ASJC Scopus subject areas
- Immunology
- Dermatology
- Infectious Diseases