Evaluation of non-specific effects of infant immunizations on early infant mortality in a southern Indian population

Lawrence Hale Moulton, Lakshmi Rahmathullah, Neal A Halsey, R. D. Thulasiraj, Joanne Katz, James M. Tielsch

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The aim of this study was to assess the relationship between receipt of routine childhood immunizations and infant mortality before 6 months of age. METHODS: This was an observational study of 10 274 infants, in a randomized trial of vitamin A supplementation, who received the study dose and survived to at least 1 week of age. The primary outcome was mortality before 6 months of age, analysed in Cox regression models as a function of vaccine receipt and gender. RESULTS: Receipt of Bacille Calmette Guerin (BCG) or diphtheria, tetanus, polio (DTP) vaccine was associated with significant reductions of one-half to two-thirds of mortality hazards; among girls, those who received both BCG and DTP experienced higher mortality than those who received only one of the two vaccines (hazards ratio 2.4; 95% confidence interval 1.2-5.0). CONCLUSION: The reduced mortality rate associated with receipt of BCG or DTP may be due to both biological and selection factors; the analyses regarding the combined effect of these vaccines and gender need to be replicated in other settings.

Original languageEnglish (US)
Pages (from-to)947-955
Number of pages9
JournalTropical Medicine and International Health
Volume10
Issue number10
DOIs
StatePublished - Oct 2005

Fingerprint

Infant Mortality
Immunization
Poliomyelitis
Diphtheria
Mortality
Tetanus
Population
Diphtheria-Tetanus Vaccine
Vaccines
Combined Vaccines
Biological Factors
Vitamin A
Proportional Hazards Models
Observational Studies
Confidence Intervals

Keywords

  • BCG
  • DTP
  • Infant mortality
  • Vaccines
  • Vitamin A

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Parasitology
  • Immunology

Cite this

Evaluation of non-specific effects of infant immunizations on early infant mortality in a southern Indian population. / Moulton, Lawrence Hale; Rahmathullah, Lakshmi; Halsey, Neal A; Thulasiraj, R. D.; Katz, Joanne; Tielsch, James M.

In: Tropical Medicine and International Health, Vol. 10, No. 10, 10.2005, p. 947-955.

Research output: Contribution to journalArticle

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