Evaluation of non-specific effects of infant immunizations on early infant mortality in a southern Indian population

Lawrence H. Moulton, Lakshmi Rahmathullah, Neal A. Halsey, R. D. Thulasiraj, Joanne Katz, James M. Tielsch

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: The aim of this study was to assess the relationship between receipt of routine childhood immunizations and infant mortality before 6 months of age. METHODS: This was an observational study of 10 274 infants, in a randomized trial of vitamin A supplementation, who received the study dose and survived to at least 1 week of age. The primary outcome was mortality before 6 months of age, analysed in Cox regression models as a function of vaccine receipt and gender. RESULTS: Receipt of Bacille Calmette Guerin (BCG) or diphtheria, tetanus, polio (DTP) vaccine was associated with significant reductions of one-half to two-thirds of mortality hazards; among girls, those who received both BCG and DTP experienced higher mortality than those who received only one of the two vaccines (hazards ratio 2.4; 95% confidence interval 1.2-5.0). CONCLUSION: The reduced mortality rate associated with receipt of BCG or DTP may be due to both biological and selection factors; the analyses regarding the combined effect of these vaccines and gender need to be replicated in other settings.

Original languageEnglish (US)
Pages (from-to)947-955
Number of pages9
JournalTropical Medicine and International Health
Volume10
Issue number10
DOIs
StatePublished - Oct 2005

Keywords

  • BCG
  • DTP
  • Infant mortality
  • Vaccines
  • Vitamin A

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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