Evaluation of new anti-infective drugs for the treatment of febrile episodes in neutropenic patients

Walter T. Hughes, Philip A. Pizzo, James C. Wade, Donald Armstrong, C. Douglas Webb, Lowell S. Young

Research output: Contribution to journalArticlepeer-review

Abstract

The use of empirical antimicrobial therapy has significantly reduced the morbidity and mortality associated with untreated infections in febrile neutropenic patients. This guideline describes clinical trials of the safety and efficacy of new antimicrobial drugs in this population of patients. Fever and neutropenia should be precisely defined in each protocol. Patients should be randomized to treatment with a new or active-control drug regimen, stratified on the basis of type of cancer and age, and treated until resolution-as defined in the protocol-is attained. Outcome should be assessed both for cases with a defined microbial etiology and for those without. Final microbiological outcome is important for cases with identified pathogens, but clinical outcome is paramount.

Original languageEnglish (US)
Pages (from-to)S206-S215
JournalClinical Infectious Diseases
Volume15
DOIs
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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