Evaluation of neutropenia and neutrophilia in preterm infants

Solomon Nittala, Girish C. Subbarao, Akhil Maheshwari

Research output: Contribution to journalReview articlepeer-review


Objective: Neutrophil counts are used routinely as part of the sepsis evaluation in newborn infants. In this article, we review the normal blood neutrophil concentrations and the clinical approach to neutropenia and neutrophilia in the neonatal period. Methods: A literature search was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. Results: Neutropenia and neutrophilia are documented frequently in premature infants. Neutropenia can be seen in up to 8% of all infants admitted to neonatal intensive care. Neutrophilia is even more common, reported in up to 40% of all preterm infants. Conclusions: Neutrophil counts should be carefully evaluated in premature neonates. Maternal and perinatal history, physical examination, and a limited laboratory assessment is usually adequate for making a diagnosis in most infants.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue numberSUPPL. 5
StatePublished - Oct 2012
Externally publishedYes


  • Leukemoid
  • Neonate
  • Neutropenia
  • Neutrophilia
  • Reference ranges

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


Dive into the research topics of 'Evaluation of neutropenia and neutrophilia in preterm infants'. Together they form a unique fingerprint.

Cite this