Evaluation of myocardial perfusion and function after kidney transplantation by gated SPECT myocardial perfusion scintigraphy

Armaghan Fard-Esfahani, Babak Fallahi, Sahar Mirpour, Ali Gholamrezanezhad, Ezatollah Abdi, Mohammad Karimi, Davood Beiki, Alireza Emami-Ardekani, Fariba Akhzari, Mojtaba Ansari, Mohammad Eftekhari

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study was to evaluate the effect of successful kidney transplantation (KT) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-SPECT) in patients suffering from end-stage renal disease. Methods: From a total of 38 patients who were candidates of KT, twenty-six patients (16 female, 10 male, mean age: 47.5 yr, range: 24-64 yr) who had successful KT were included. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method, before and after surgery (mean: 24 months). Perfusion and function status was evaluated by qualitative and semiquantitative parameters. Results: Our data showed qualitative evidence of perfusion and functional abnormality in pre-transplant scans as follows: Abnormal perfusion in left anterior descending (LAD), left circumflex (LCX) and right coronary artery (RCA) territories in 42.5%, 53.8% and 65.4% of cases, respectively; dilation in 57.7% and inhomogenity of uptake in 53.8% of cases. However no statistically significant change was noted after transplantation, i.e. p value for all semiquantitative values including summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS), summed motion score (SMS), summed thickening score (STS), ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), and stroke volume (SV) was greater than 0.05. Conclusion: Renal transplantation may not have considerable long term effect on myocardial perfusion and function in patients with chronic renal failure. This could be due to either non-reversible myocardial changes or continuing effect of degrading factors on the myocardium.

Original languageEnglish (US)
Pages (from-to)20-24
Number of pages5
JournalIranian Journal of Nuclear Medicine
Volume20
Issue number2
StatePublished - Sep 1 2012
Externally publishedYes

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Myocardial Perfusion Imaging
Perfusion Imaging
Single-Photon Emission-Computed Tomography
Kidney Transplantation
Perfusion
Chronic Kidney Failure
Left Ventricular Function
Stroke Volume
Dilatation
Coronary Vessels
Myocardium
Transplantation
Transplants

Keywords

  • Gated-SPECT
  • Kidney transplantation
  • Myocardial function
  • Myocardial perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Fard-Esfahani, A., Fallahi, B., Mirpour, S., Gholamrezanezhad, A., Abdi, E., Karimi, M., ... Eftekhari, M. (2012). Evaluation of myocardial perfusion and function after kidney transplantation by gated SPECT myocardial perfusion scintigraphy. Iranian Journal of Nuclear Medicine, 20(2), 20-24.

Evaluation of myocardial perfusion and function after kidney transplantation by gated SPECT myocardial perfusion scintigraphy. / Fard-Esfahani, Armaghan; Fallahi, Babak; Mirpour, Sahar; Gholamrezanezhad, Ali; Abdi, Ezatollah; Karimi, Mohammad; Beiki, Davood; Emami-Ardekani, Alireza; Akhzari, Fariba; Ansari, Mojtaba; Eftekhari, Mohammad.

In: Iranian Journal of Nuclear Medicine, Vol. 20, No. 2, 01.09.2012, p. 20-24.

Research output: Contribution to journalArticle

Fard-Esfahani, A, Fallahi, B, Mirpour, S, Gholamrezanezhad, A, Abdi, E, Karimi, M, Beiki, D, Emami-Ardekani, A, Akhzari, F, Ansari, M & Eftekhari, M 2012, 'Evaluation of myocardial perfusion and function after kidney transplantation by gated SPECT myocardial perfusion scintigraphy', Iranian Journal of Nuclear Medicine, vol. 20, no. 2, pp. 20-24.
Fard-Esfahani, Armaghan ; Fallahi, Babak ; Mirpour, Sahar ; Gholamrezanezhad, Ali ; Abdi, Ezatollah ; Karimi, Mohammad ; Beiki, Davood ; Emami-Ardekani, Alireza ; Akhzari, Fariba ; Ansari, Mojtaba ; Eftekhari, Mohammad. / Evaluation of myocardial perfusion and function after kidney transplantation by gated SPECT myocardial perfusion scintigraphy. In: Iranian Journal of Nuclear Medicine. 2012 ; Vol. 20, No. 2. pp. 20-24.
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abstract = "Introduction: The aim of this study was to evaluate the effect of successful kidney transplantation (KT) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-SPECT) in patients suffering from end-stage renal disease. Methods: From a total of 38 patients who were candidates of KT, twenty-six patients (16 female, 10 male, mean age: 47.5 yr, range: 24-64 yr) who had successful KT were included. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method, before and after surgery (mean: 24 months). Perfusion and function status was evaluated by qualitative and semiquantitative parameters. Results: Our data showed qualitative evidence of perfusion and functional abnormality in pre-transplant scans as follows: Abnormal perfusion in left anterior descending (LAD), left circumflex (LCX) and right coronary artery (RCA) territories in 42.5{\%}, 53.8{\%} and 65.4{\%} of cases, respectively; dilation in 57.7{\%} and inhomogenity of uptake in 53.8{\%} of cases. However no statistically significant change was noted after transplantation, i.e. p value for all semiquantitative values including summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS), summed motion score (SMS), summed thickening score (STS), ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), and stroke volume (SV) was greater than 0.05. Conclusion: Renal transplantation may not have considerable long term effect on myocardial perfusion and function in patients with chronic renal failure. This could be due to either non-reversible myocardial changes or continuing effect of degrading factors on the myocardium.",
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AU - Fard-Esfahani, Armaghan

AU - Fallahi, Babak

AU - Mirpour, Sahar

AU - Gholamrezanezhad, Ali

AU - Abdi, Ezatollah

AU - Karimi, Mohammad

AU - Beiki, Davood

AU - Emami-Ardekani, Alireza

AU - Akhzari, Fariba

AU - Ansari, Mojtaba

AU - Eftekhari, Mohammad

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N2 - Introduction: The aim of this study was to evaluate the effect of successful kidney transplantation (KT) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-SPECT) in patients suffering from end-stage renal disease. Methods: From a total of 38 patients who were candidates of KT, twenty-six patients (16 female, 10 male, mean age: 47.5 yr, range: 24-64 yr) who had successful KT were included. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method, before and after surgery (mean: 24 months). Perfusion and function status was evaluated by qualitative and semiquantitative parameters. Results: Our data showed qualitative evidence of perfusion and functional abnormality in pre-transplant scans as follows: Abnormal perfusion in left anterior descending (LAD), left circumflex (LCX) and right coronary artery (RCA) territories in 42.5%, 53.8% and 65.4% of cases, respectively; dilation in 57.7% and inhomogenity of uptake in 53.8% of cases. However no statistically significant change was noted after transplantation, i.e. p value for all semiquantitative values including summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS), summed motion score (SMS), summed thickening score (STS), ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), and stroke volume (SV) was greater than 0.05. Conclusion: Renal transplantation may not have considerable long term effect on myocardial perfusion and function in patients with chronic renal failure. This could be due to either non-reversible myocardial changes or continuing effect of degrading factors on the myocardium.

AB - Introduction: The aim of this study was to evaluate the effect of successful kidney transplantation (KT) on myocardial perfusion and left ventricular function by both qualitative (visual) interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography (gated-SPECT) in patients suffering from end-stage renal disease. Methods: From a total of 38 patients who were candidates of KT, twenty-six patients (16 female, 10 male, mean age: 47.5 yr, range: 24-64 yr) who had successful KT were included. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography (Gated-SPECT) method, before and after surgery (mean: 24 months). Perfusion and function status was evaluated by qualitative and semiquantitative parameters. Results: Our data showed qualitative evidence of perfusion and functional abnormality in pre-transplant scans as follows: Abnormal perfusion in left anterior descending (LAD), left circumflex (LCX) and right coronary artery (RCA) territories in 42.5%, 53.8% and 65.4% of cases, respectively; dilation in 57.7% and inhomogenity of uptake in 53.8% of cases. However no statistically significant change was noted after transplantation, i.e. p value for all semiquantitative values including summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS), summed motion score (SMS), summed thickening score (STS), ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), and stroke volume (SV) was greater than 0.05. Conclusion: Renal transplantation may not have considerable long term effect on myocardial perfusion and function in patients with chronic renal failure. This could be due to either non-reversible myocardial changes or continuing effect of degrading factors on the myocardium.

KW - Gated-SPECT

KW - Kidney transplantation

KW - Myocardial function

KW - Myocardial perfusion

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