Evaluation of mixtures of morphine and d-amphetamine for subjective and physiological effects

Donald R. Jasinski, Kenzie L. Preston

Research output: Contribution to journalArticlepeer-review


Combinations of morphine and d-amphetamine have been shown to be more effective in relieving pathological and experimental pain with fewer side effects than morphine alone. Subjective, physiological and behavioral effects of the combination were assessed in the present study to determine whether the abuse liability of the combination might also be enhanced. Single intramuscular doses of morphine and d-amphetamine alone and in combination were tested under double-blind conditions in 10 adult, male, nondependent substance abusers. Morphine and amphetamine alone increased scores on subjective effect measures including the Morphine-Benzedrine Group (MBG) (euphoria) and liking scales. In general, the combination produced greater euphoria than that produced by either drug alone. In contrast, many physiological effects of the drugs were mutually antagonized. Thus, the combination of morphine and d-amphetamine has a greater potential to be abused because of the additive euphoria and a lessening of side effects.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalDrug and alcohol dependence
Issue number1
StatePublished - May 1986


  • Abuse potential
  • Combination
  • Morphine
  • d-Amphetamine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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