Evaluation of miLINC to shorten time to treatment for rifampicinresistant Mycobacterium tuberculosis

J. E. Farley, J. McKenzie-White, R. Bollinger, H. Hong, K. Lowensen, L. W. Chang, P. Stamper, L. Berrie, F. Olsen, L. Isherwood, N. Ndjeka, W. Stevens

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Achieving the 90-90-90 targets for tuberculosis (TB) will require interventions that enhance diagnosis, linkage, treatment and adherence to care. As a first step in the process, our team designed a suite of smartphone applications known as miLINC to improve time from diagnosis to treatment initiation in drugresistant TB patients. SETTING: Three clinical locations in a large, peri-urban district in KwaZulu-Natal, South Africa. OBJECTIVE : To assess the acceptability, feasibility and impact of the miLINC mobile health applications as a solution to reducing the time from presentation to treatment initiation of rifampicin-resistant (RR) TB patients. METHODS : We used a prospective, observational quality improvement evaluation of miLINC's impact among newly diagnosed patients with RR-TB. RESULT S : A convenience sample comprising details of 6341 patients with presumptive TB were entered into miLINC. Of the 631 TB-positive sputum specimens, 41 (6.5%) were found to be RR-TB. The mean time from clinical presentation to RR-TB treatment initiation was 3 days, 21 h, 17 min. CONCLUS ION: This is the first study to suggest that the time from presentation to diagnosis and to treatment initiation for patients with RR-TB can be significantly improved using an integrated approach combining technology with appropriate human resources.

Original languageEnglish (US)
Pages (from-to)980-988
Number of pages9
JournalInternational Journal of Tuberculosis and Lung Disease
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2019

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Mycobacterium tuberculosis
Tuberculosis
Rifampin
Therapeutics
Mobile Applications
Telemedicine
Quality Improvement
South Africa
Sputum
Technology

Keywords

  • Linkage to care
  • Mhealth
  • South Africa
  • Treatment initiation
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Evaluation of miLINC to shorten time to treatment for rifampicinresistant Mycobacterium tuberculosis. / Farley, J. E.; McKenzie-White, J.; Bollinger, R.; Hong, H.; Lowensen, K.; Chang, L. W.; Stamper, P.; Berrie, L.; Olsen, F.; Isherwood, L.; Ndjeka, N.; Stevens, W.

In: International Journal of Tuberculosis and Lung Disease, Vol. 23, No. 9, 01.09.2019, p. 980-988.

Research output: Contribution to journalArticle

Farley, JE, McKenzie-White, J, Bollinger, R, Hong, H, Lowensen, K, Chang, LW, Stamper, P, Berrie, L, Olsen, F, Isherwood, L, Ndjeka, N & Stevens, W 2019, 'Evaluation of miLINC to shorten time to treatment for rifampicinresistant Mycobacterium tuberculosis', International Journal of Tuberculosis and Lung Disease, vol. 23, no. 9, pp. 980-988. https://doi.org/10.5588/ijtld.18.0503
Farley, J. E. ; McKenzie-White, J. ; Bollinger, R. ; Hong, H. ; Lowensen, K. ; Chang, L. W. ; Stamper, P. ; Berrie, L. ; Olsen, F. ; Isherwood, L. ; Ndjeka, N. ; Stevens, W. / Evaluation of miLINC to shorten time to treatment for rifampicinresistant Mycobacterium tuberculosis. In: International Journal of Tuberculosis and Lung Disease. 2019 ; Vol. 23, No. 9. pp. 980-988.
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