Evaluation of left ventricular outflow tract obstruction with four-dimensional phase contrast magnetic resonance imaging in patients with hypertrophic cardiomyopathy-a pilot study

Linda C. Chu, Kristin Porter, Celia Pamela Corona-Villalobos, Mehmet Akif Gülsün, Steven M. Shea, Michael Markl, Theodore P. Abraham, David A. Bluemke, Ihab R. Kamel, Stefan L. Zimmerman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study aimed to validate 4-dimensional phase contrast (4D PC) cine magnetic resonance imaging (MRI) as a means of evaluating left ventricular outflow tract (LVOT) obstruction in patients with hypertrophic cardiomyopathy (HCM). Methods: In this institutional review board-approved prospective study, 23 patients with suspected HCM from October 2012 to September 2013 underwent 4D PC MRI. Postprocessed 4D PC pathline cine data were reviewed by 2 blinded reviewers to determine presence or absence of LVOT obstruction. Sensitivity, specificity, and accuracy in 4D PC qualitative and quantitative assessment of LVOTobstruction were calculated using echo as reference standard. Results: Consensus interpretation of 4D PC showed 100.0% (7/7) sensitivity, 75.0% specificity (12/16), and 82.6% (19/23) accuracy in assessment of LVOT obstruction. The 4D PC quantitative estimates of LVOT gradient have 71.4% (5/7) sensitivity, 93.8% (15/16) specificity, and 87.0% (20/23) accuracy in evaluation of LVOT obstruction compared with echo. Conclusions: The 4D PC MRI can assess for LVOT obstruction in HCM patients.

Original languageEnglish (US)
Pages (from-to)937-940
Number of pages4
JournalJournal of computer assisted tomography
Volume40
Issue number6
DOIs
StatePublished - 2016

Keywords

  • Cardiac magnetic resonance
  • Four-dimensional phase contrast
  • Hypertrophic cardiomyopathy
  • Left ventricular outflow tract obstruction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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