Abstract
Hyperpolarized 13C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized 13C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inhibitor reduced conversion of 13C-pyruvate to alanine without affecting conversion of pyruvate to lactate. These results illustrate the ability to monitor biomarkers for responses to antimetabolic therapy in real-time, paving the way for clinical development of imaging biomarkers to monitor metabolic pharmacodynamics.
Original language | English (US) |
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Pages (from-to) | 4190-4195 |
Number of pages | 6 |
Journal | Cancer Research |
Volume | 73 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2013 |
ASJC Scopus subject areas
- Oncology
- Cancer Research