Evaluation of in vitro and in vivo antibacterial activity of dobutamine hydrochloride

A. Sarkar, K. A. Kumar, N. K. Dutta, P. Chakraborty, S. G. Dastidar

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To determine the in vitro and in vivo antibacterial activity of a cardiovascular drug dobutamine hydrochloride. Methods: The minimum inhibitory concentration (MIC) of dobutamine was determined both by agar and broth dilution methods against 331 strains of bacteria from three gram positive and 13 gram negative genera. The antibacterial action of dobutamine was further tested in animal models. Results: Dobutamine was seen to possess powerful inhibitory action (5-200μg/mL) against most test bacteria in in vitro studies. It was bacteriostatic in nature. In vivo studies showed that the drug offered significant protection (p<0.001) to mice challenged with a virulent bacterium. Conclusion: Dobutamine showed remarkable antibacterial property against several pathogenic bacteria. Its potential as an antibacterial agent may be confirmed after further pharmacological studies.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalIndian Journal of Medical Microbiology
Volume21
Issue number3
StatePublished - Jul 1 2003
Externally publishedYes

Keywords

  • Antimicrobial
  • Cardiovascular drug
  • Dobutamine

ASJC Scopus subject areas

  • Microbiology (medical)

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