Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia

J. J. Sevigny, S. M. Albert, M. P. McDermott, Justin Charles McArthur, Ned Sacktor, K. Conant, G. Schifitto, O. A. Selnes, Y. Stern, D. R. McClernon, D. Palumbo, K. Kieburtz, G. Riggs, B. Cohen, L. G. Epstein, K. Marder

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate whether baseline levels of plasma and CSF HIV RNA, tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2), or macrophage colony stimulating factor (M-CSF) are predictors of incident HIV-associated dementia (HIVD) in a cohort with advanced HIV infection. Methods: A total of 203 nondemented subjects with CD4 lymphocyte counts less than 200/μL, or 10) were associated with time to HIVD; log10 levels of plasma TNFα (HR 3.07, p = 0.03) and CSF MCP-1 (HR = 3.36, p = 0.06) tended to be associated with time to HIVD. Conclusion: The lack of association between baseline plasma and CSF HIV RNA levels and incident dementia suggests highly active antiretroviral therapy may be affecting CNS viral dynamics, leading to lower HIV RNA levels, and therefore weakening the utility of baseline HIV RNA levels as predictors of HIV-associated dementia.

Original languageEnglish (US)
Pages (from-to)2084-2090
Number of pages7
JournalNeurology
Volume63
Issue number11
StatePublished - Dec 14 2004

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AIDS Dementia Complex
Biomarkers
HIV
RNA
Chemokine CCL2
Tumor Necrosis Factor-alpha
Macrophage Colony-Stimulating Factor
Matrix Metalloproteinase 2
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
HIV Infections
Dementia
immune RNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sevigny, J. J., Albert, S. M., McDermott, M. P., McArthur, J. C., Sacktor, N., Conant, K., ... Marder, K. (2004). Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology, 63(11), 2084-2090.

Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. / Sevigny, J. J.; Albert, S. M.; McDermott, M. P.; McArthur, Justin Charles; Sacktor, Ned; Conant, K.; Schifitto, G.; Selnes, O. A.; Stern, Y.; McClernon, D. R.; Palumbo, D.; Kieburtz, K.; Riggs, G.; Cohen, B.; Epstein, L. G.; Marder, K.

In: Neurology, Vol. 63, No. 11, 14.12.2004, p. 2084-2090.

Research output: Contribution to journalArticle

Sevigny, JJ, Albert, SM, McDermott, MP, McArthur, JC, Sacktor, N, Conant, K, Schifitto, G, Selnes, OA, Stern, Y, McClernon, DR, Palumbo, D, Kieburtz, K, Riggs, G, Cohen, B, Epstein, LG & Marder, K 2004, 'Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia', Neurology, vol. 63, no. 11, pp. 2084-2090.
Sevigny JJ, Albert SM, McDermott MP, McArthur JC, Sacktor N, Conant K et al. Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology. 2004 Dec 14;63(11):2084-2090.
Sevigny, J. J. ; Albert, S. M. ; McDermott, M. P. ; McArthur, Justin Charles ; Sacktor, Ned ; Conant, K. ; Schifitto, G. ; Selnes, O. A. ; Stern, Y. ; McClernon, D. R. ; Palumbo, D. ; Kieburtz, K. ; Riggs, G. ; Cohen, B. ; Epstein, L. G. ; Marder, K. / Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. In: Neurology. 2004 ; Vol. 63, No. 11. pp. 2084-2090.
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AU - Sacktor, Ned

AU - Conant, K.

AU - Schifitto, G.

AU - Selnes, O. A.

AU - Stern, Y.

AU - McClernon, D. R.

AU - Palumbo, D.

AU - Kieburtz, K.

AU - Riggs, G.

AU - Cohen, B.

AU - Epstein, L. G.

AU - Marder, K.

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AB - Objective: To evaluate whether baseline levels of plasma and CSF HIV RNA, tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2), or macrophage colony stimulating factor (M-CSF) are predictors of incident HIV-associated dementia (HIVD) in a cohort with advanced HIV infection. Methods: A total of 203 nondemented subjects with CD4 lymphocyte counts less than 200/μL, or 10) were associated with time to HIVD; log10 levels of plasma TNFα (HR 3.07, p = 0.03) and CSF MCP-1 (HR = 3.36, p = 0.06) tended to be associated with time to HIVD. Conclusion: The lack of association between baseline plasma and CSF HIV RNA levels and incident dementia suggests highly active antiretroviral therapy may be affecting CNS viral dynamics, leading to lower HIV RNA levels, and therefore weakening the utility of baseline HIV RNA levels as predictors of HIV-associated dementia.

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