Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women

Amy B. Wisniewski, Tam T. Nguyen, Adrian S. Dobs

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women. Methods: Participants were tested with a randomized, double-blind design on the Identical Pictures, Cube Comparisons, Building Memory and Shape Memory tasks before and after 4 months of hormone treatment. Results: Women receiving estrogen and methyltestosterone maintained a steady level of performance on the Building Memory task, whereas those receiving estrogen alone showed a decrease in performance. Conclusions: These results indicate that the addition of testosterone to high-dose estrogen replacement exerts a protective effect on memory performance in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)150-155
Number of pages6
JournalHormone Research
Volume58
Issue number3
DOIs
StatePublished - Oct 17 2002

Keywords

  • Cognition
  • Memory
  • Menopause
  • Perception
  • Sex steroid hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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