@article{7e3f0774dee3495dbae4161777d75fbc,
title = "Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion: The Central Vein Occlusion Study Group M Report",
abstract = "Purpose: To evaluate the efficacy of macular grid photocoagulation in preserving or improving central visual acuity in eyes with macular edema due to central vein occlusion (CVO) and best-corrected visual acuity of 20/50 or poorer. Methods: Patients with angiographically documented macular edema due to CVO were entered into a multicenter randomized controlled clinical trial supported by the National Eye Institute. Eligibility was determined based on both clinical examination findings and photographic documentation evaluated at a photograph reading center. Eyes were assigned randomly to macular grid photocoagulation (77 eyes) or no treatment (78 eyes). Patients were followed every 4 months for 3 years or until the end of the study. The outcome measure was visual acuity. Results: The study population consisted of 155 eyes in 155 patients. There was no difference between treated and untreated eyes in visual acuity at any point during the follow-up period. Initial median visual acuity was 20/160 in treated eyes and 20/ 125 in control eyes. Final median visual acuity was 20/200 in treated eyes and 20/160 in control eyes. However, treatment clearly reduced angiographic evidence of macular edema. Conclusion: The results of this study do not support a recommendation for macular grid photocoagulation for the population meeting the Central Vein Occlusion Study macular edema group eligibility criteria.",
author = "{The Central Vein Occlusion Study Group} and Clarkson, {John G.} and Elaine Chuang and Donald Gass and Maria Pedroso and Tony Cubillas and Duria, {Erlinda S.} and Hess, {Ditte J.} and Isabel Rams and Marguerite Ball and Alex Gutierrez and Nayla Muniz and June Thompson and Michele Pall and Pappas, {Charles J.} and Daniel Finkelstein and Arnall Patz and Dolores Rytel and Judy Belt and Dennis Cain and Terri Cain and David Emmert and Terry George and Mark Herring and Pete Sotirakos and Orth, {David H.} and Flood, {Timothy P.} and Packo, {Kirk H.} and Toni Larsen and Nancy Perez and Doug Bryant and Don Doherty and Jay Fitzgerald and Martha Gordon and Cynthia Holod and Kathy Kwiatkowski and Celeste MacLeod and Chris Morrison and Charlotte Westcott and Klein, {Michael L.} and David Wilson and Weleber, {Richard G.} and Susan Nolte and Nancy Hurlburt and Mark Evans and Patrick Wallace and Peter Steinkamp and Debora Funkner and Cathy Gordon and Clement Trempe and Alex Jalkh",
note = "Funding Information: Originally received: December 22, 1994. Revision accepted: July 6, 1995. *Members of the Central Vein Occlusion Study Group are listed in the Appendix at the end of this article. Supported by grants EY06752, EY07525, EY06749, EY06751, EY06750, EY07813, EY06797, EY06777, EY06730, EY07788, EY06753, and EY06815 from the National Eye Institute, National Institutes of Health, Bethesda, Maryland. Reprint requests to John G. Clarkson, MD, Bascom Palmer Eye Institute, 900 NW 17th St, Miami, FL 33136.",
year = "1995",
doi = "10.1016/S0161-6420(95)30849-4",
language = "English (US)",
volume = "102",
pages = "1425--1433",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "10",
}