Evaluation of fast atom bombardment mass spectrometry for assessing the oxidation states of disulfide‐containing peptides

B. S. Larsen; J. A. Yergey; R. J. Cotter

doi:10.1002/bms.1200121003

Evaluation of fast atom bombardment mass spectrometry for assessing the oxidation states of disulfide‐containing peptides

B. S. Larsen, J. A. Yergey, R. J. Cotter

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8 Scopus citations

Abstract

Positive and negative ion fast atom bombardment (FAB) mass spectra of the molecular ion region of calcitonin using several solution matrices produce an isotopic distribution which is indicative of a mixture of reduced and oxidized disulfide bonds. The insensitivity of the distribution to the choice of matrix and positive/negative ion mode suggest that the spectra reflect the natural abundance of reduced calcitonin in the sample, rather than an artifact of the fast atom bombardment technique.

Original language	English (US)
Pages (from-to)	586-587
Number of pages	2
Journal	Biological Mass Spectrometry
Volume	12
Issue number	10
DOIs	https://doi.org/10.1002/bms.1200121003
State	Published - Oct 1985
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

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10.1002/bms.1200121003

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title = "Evaluation of fast atom bombardment mass spectrometry for assessing the oxidation states of disulfide‐containing peptides",

abstract = "Positive and negative ion fast atom bombardment (FAB) mass spectra of the molecular ion region of calcitonin using several solution matrices produce an isotopic distribution which is indicative of a mixture of reduced and oxidized disulfide bonds. The insensitivity of the distribution to the choice of matrix and positive/negative ion mode suggest that the spectra reflect the natural abundance of reduced calcitonin in the sample, rather than an artifact of the fast atom bombardment technique.",

author = "Larsen, {B. S.} and Yergey, {J. A.} and Cotter, {R. J.}",

year = "1985",

month = oct,

doi = "10.1002/bms.1200121003",

language = "English (US)",

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publisher = "John Wiley and Sons Ltd",

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AU - Larsen, B. S.

AU - Yergey, J. A.

AU - Cotter, R. J.

PY - 1985/10

Y1 - 1985/10

N2 - Positive and negative ion fast atom bombardment (FAB) mass spectra of the molecular ion region of calcitonin using several solution matrices produce an isotopic distribution which is indicative of a mixture of reduced and oxidized disulfide bonds. The insensitivity of the distribution to the choice of matrix and positive/negative ion mode suggest that the spectra reflect the natural abundance of reduced calcitonin in the sample, rather than an artifact of the fast atom bombardment technique.

AB - Positive and negative ion fast atom bombardment (FAB) mass spectra of the molecular ion region of calcitonin using several solution matrices produce an isotopic distribution which is indicative of a mixture of reduced and oxidized disulfide bonds. The insensitivity of the distribution to the choice of matrix and positive/negative ion mode suggest that the spectra reflect the natural abundance of reduced calcitonin in the sample, rather than an artifact of the fast atom bombardment technique.

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Evaluation of fast atom bombardment mass spectrometry for assessing the oxidation states of disulfide‐containing peptides

Abstract

ASJC Scopus subject areas

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