Evaluation of fast atom bombardment mass spectrometry for assessing the oxidation states of disulfide‐containing peptides

B. S. Larsen, J. A. Yergey, R. J. Cotter

Research output: Contribution to journalArticlepeer-review

Abstract

Positive and negative ion fast atom bombardment (FAB) mass spectra of the molecular ion region of calcitonin using several solution matrices produce an isotopic distribution which is indicative of a mixture of reduced and oxidized disulfide bonds. The insensitivity of the distribution to the choice of matrix and positive/negative ion mode suggest that the spectra reflect the natural abundance of reduced calcitonin in the sample, rather than an artifact of the fast atom bombardment technique.

Original languageEnglish (US)
Pages (from-to)586-587
Number of pages2
JournalBiological Mass Spectrometry
Volume12
Issue number10
DOIs
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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