Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.

Ping Zhao, Manuela de L.T. Vieira, Joseph A. Grillo, Pengfei Song, Ta Chen Wu, Jenny H. Zheng, Vikram Arya, Eva Gil Berglund, Arthur J. Atkinson, Yuichi Sugiyama, K. Sandy Pang, Kellie S. Reynolds, Darrell R. Abernethy, Lei Zhang, Lawrence J. Lesko, Shiew Mei Huang

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Medicine & Life Sciences