Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention

Jessica L. Unick, Patricia E. Hogan, Rebecca H. Neiberg, Lawrence J Cheskin, Gareth R. Dutton, Gina Evans-Hudnall, Robert Jeffery, Abbas E. Kitabchi, Julie A. Nelson, F. Xavier Pi-Sunyer, Delia Smith West, Rena R. Wing

Research output: Contribution to journalArticle

Abstract

Objective Weight losses in lifestyle interventions are variable, yet prediction of long-term success is difficult. The utility of using various weight loss thresholds in the first 2 months of treatment for predicting 1-year outcomes was examined. Methods Participants included 2327 adults with type 2 diabetes (BMI:35.8 ± 6.0) randomized to the intensive lifestyle intervention (ILI) of the Look AHEAD trial. ILI included weekly behavioral sessions designed to increase physical activity and reduce caloric intake. 1-month, 2-month, and 1-year weight changes were calculated. Results Participants failing to achieve a ≥2% weight loss at Month 1 were 5.6 (95% CI:4.5, 7.0) times more likely to also not achieve a ≥10% weight loss at Year 1, compared to those losing ≥2% initially. These odds were increased to 11.6 (95% CI:8.6, 15.6) when using a 3% weight loss threshold at Month 2. Only 15.2% and 8.2% of individuals failing to achieve the ≥2% and ≥3% thresholds at Months 1 and 2, respectively, go on to achieve a ≥10% weight loss at Year 1. Conclusions Given the association between initial and 1-year weight loss, the first few months of treatment may be an opportune time to identify those who are unsuccessful and utilize rescue efforts. Trial Registration clinicaltrials.gov Identifier: NCT00017953

Original languageEnglish (US)
Pages (from-to)1608-1616
Number of pages9
JournalObesity
Volume22
Issue number7
DOIs
StatePublished - 2014

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Life Style
Weight Loss
Energy Intake
Type 2 Diabetes Mellitus
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Unick, J. L., Hogan, P. E., Neiberg, R. H., Cheskin, L. J., Dutton, G. R., Evans-Hudnall, G., ... Wing, R. R. (2014). Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. Obesity, 22(7), 1608-1616. https://doi.org/10.1002/oby.20777

Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. / Unick, Jessica L.; Hogan, Patricia E.; Neiberg, Rebecca H.; Cheskin, Lawrence J; Dutton, Gareth R.; Evans-Hudnall, Gina; Jeffery, Robert; Kitabchi, Abbas E.; Nelson, Julie A.; Pi-Sunyer, F. Xavier; West, Delia Smith; Wing, Rena R.

In: Obesity, Vol. 22, No. 7, 2014, p. 1608-1616.

Research output: Contribution to journalArticle

Unick, JL, Hogan, PE, Neiberg, RH, Cheskin, LJ, Dutton, GR, Evans-Hudnall, G, Jeffery, R, Kitabchi, AE, Nelson, JA, Pi-Sunyer, FX, West, DS & Wing, RR 2014, 'Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention', Obesity, vol. 22, no. 7, pp. 1608-1616. https://doi.org/10.1002/oby.20777
Unick JL, Hogan PE, Neiberg RH, Cheskin LJ, Dutton GR, Evans-Hudnall G et al. Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. Obesity. 2014;22(7):1608-1616. https://doi.org/10.1002/oby.20777
Unick, Jessica L. ; Hogan, Patricia E. ; Neiberg, Rebecca H. ; Cheskin, Lawrence J ; Dutton, Gareth R. ; Evans-Hudnall, Gina ; Jeffery, Robert ; Kitabchi, Abbas E. ; Nelson, Julie A. ; Pi-Sunyer, F. Xavier ; West, Delia Smith ; Wing, Rena R. / Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. In: Obesity. 2014 ; Vol. 22, No. 7. pp. 1608-1616.
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