Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

Wilma E. Meijs; Jacobus D M Herscheid; Hidde J. Haisma; Herbert M. Pinedo

doi:10.1016/0883-2889(92)90170-J

Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

Wilma E. Meijs, Jacobus D M Herscheid, Hidde J. Haisma, Herbert M. Pinedo

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90 Scopus citations

Abstract

Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with ⁸⁸Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

Original language	English (US)
Pages (from-to)	1443-1447
Number of pages	5
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	43
Issue number	12
DOIs	https://doi.org/10.1016/0883-2889(92)90170-J
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Radiation

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title = "Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89",

abstract = "Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.",

author = "Meijs, {Wilma E.} and Herscheid, {Jacobus D M} and Haisma, {Hidde J.} and Pinedo, {Herbert M.}",

year = "1992",

doi = "10.1016/0883-2889(92)90170-J",

language = "English (US)",

volume = "43",

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AU - Meijs, Wilma E.

AU - Herscheid, Jacobus D M

AU - Haisma, Hidde J.

AU - Pinedo, Herbert M.

PY - 1992

Y1 - 1992

N2 - Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

AB - Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

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JO - International Journal of Radiation Applications and Instrumentation. Part

JF - International Journal of Radiation Applications and Instrumentation. Part

IS - 12

ER -

Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

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