Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

Wilma E. Meijs, Jacobus D M Herscheid, Hidde J. Haisma, Herbert M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

Original languageEnglish (US)
Pages (from-to)1443-1447
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume43
Issue number12
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Radiation

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