Evaluation of deprenyl for cocaine-like discriminative stimulus effects in rats

Sevil Yasar, Charles W. Schindler, Eric B. Thorndike, Steven R. Goldberg

Research output: Contribution to journalArticle

Abstract

The antiparkinsonian agent l-deprenyl is metabolized to l-methamphetamine and l-amphetamine and, at higher doses, can facilitate the release and inhibit the reuptake of dopamine. Since l-deprenyl can affect dopamine release and reuptake it was important to evaluate it for cocaine-like discriminative stimulus effects. Male Fisher rats were trained to discriminate cocaine (10 mg/kg, i.p.) from saline in a two-lever, operant-conditioning procedure using schedules of food-delivery or stimulus-shock termination. l-Deprenyl (17 mg/kg, i.p.) produced full generalization to cocaine under the food-delivery schedule but this or higher doses produced only partial generalization to cocaine under the stimulus-shock termination schedule. d-Deprenyl produced full generalization to cocaine under both schedules at i.p. doses of 5.6 to 10 mg/kg. These cocaine-like discriminative stimulus effects occur only at doses that are well above the clinically relevant dose range for l-deprenyl.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalEuropean Journal of Pharmacology
Volume259
Issue number3
DOIs
StatePublished - Jul 11 1994

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Keywords

  • Cocaine
  • Deprenyl
  • Drug discrimination

ASJC Scopus subject areas

  • Pharmacology

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