TY - JOUR
T1 - Evaluation of deprenyl for cocaine-like discriminative stimulus effects in rats
AU - Yasar, Sevil
AU - Schindler, Charles W.
AU - Thorndike, Eric B.
AU - Goldberg, Steven R.
PY - 1994/7/11
Y1 - 1994/7/11
N2 - The antiparkinsonian agent l-deprenyl is metabolized to l-methamphetamine and l-amphetamine and, at higher doses, can facilitate the release and inhibit the reuptake of dopamine. Since l-deprenyl can affect dopamine release and reuptake it was important to evaluate it for cocaine-like discriminative stimulus effects. Male Fisher rats were trained to discriminate cocaine (10 mg/kg, i.p.) from saline in a two-lever, operant-conditioning procedure using schedules of food-delivery or stimulus-shock termination. l-Deprenyl (17 mg/kg, i.p.) produced full generalization to cocaine under the food-delivery schedule but this or higher doses produced only partial generalization to cocaine under the stimulus-shock termination schedule. d-Deprenyl produced full generalization to cocaine under both schedules at i.p. doses of 5.6 to 10 mg/kg. These cocaine-like discriminative stimulus effects occur only at doses that are well above the clinically relevant dose range for l-deprenyl.
AB - The antiparkinsonian agent l-deprenyl is metabolized to l-methamphetamine and l-amphetamine and, at higher doses, can facilitate the release and inhibit the reuptake of dopamine. Since l-deprenyl can affect dopamine release and reuptake it was important to evaluate it for cocaine-like discriminative stimulus effects. Male Fisher rats were trained to discriminate cocaine (10 mg/kg, i.p.) from saline in a two-lever, operant-conditioning procedure using schedules of food-delivery or stimulus-shock termination. l-Deprenyl (17 mg/kg, i.p.) produced full generalization to cocaine under the food-delivery schedule but this or higher doses produced only partial generalization to cocaine under the stimulus-shock termination schedule. d-Deprenyl produced full generalization to cocaine under both schedules at i.p. doses of 5.6 to 10 mg/kg. These cocaine-like discriminative stimulus effects occur only at doses that are well above the clinically relevant dose range for l-deprenyl.
KW - Cocaine
KW - Deprenyl
KW - Drug discrimination
UR - http://www.scopus.com/inward/record.url?scp=0028200345&partnerID=8YFLogxK
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U2 - 10.1016/0014-2999(94)90650-5
DO - 10.1016/0014-2999(94)90650-5
M3 - Article
C2 - 7982450
AN - SCOPUS:0028200345
SN - 0014-2999
VL - 259
SP - 243
EP - 250
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -