TY - JOUR
T1 - Evaluation of current clinical trial methodology in analgesimetry based on experts' opinions and analysis of several analgesic studies
AU - Sriwatanakul, Kampon
AU - Lasagna, Louis
AU - Cox, Christopher
PY - 1983/9
Y1 - 1983/9
N2 - There is general agreement that the controlled clinical trial is the best method for analgesic evaluation. Current practice in clinical analgesimetry, however, varies considerably with regard to design, measurement of pain, and statistical analysis. We attempted to assess the degree of this diversity by a questionnaire survey of a sample of investigators who are currently conducting clinical pain studies. To examine how various statistical methods perform in practice, we reanalyzed data from four of our published analgesic studies using a number of standard methods.
AB - There is general agreement that the controlled clinical trial is the best method for analgesic evaluation. Current practice in clinical analgesimetry, however, varies considerably with regard to design, measurement of pain, and statistical analysis. We attempted to assess the degree of this diversity by a questionnaire survey of a sample of investigators who are currently conducting clinical pain studies. To examine how various statistical methods perform in practice, we reanalyzed data from four of our published analgesic studies using a number of standard methods.
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U2 - 10.1038/clpt.1983.168
DO - 10.1038/clpt.1983.168
M3 - Article
C2 - 6883903
AN - SCOPUS:0020510140
SN - 0009-9236
VL - 34
SP - 277
EP - 283
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 3
ER -