Evaluation of current clinical trial methodology in analgesimetry based on experts' opinions and analysis of several analgesic studies

Kampon Sriwatanakul, Louis Lasagna, Christopher Cox

Research output: Contribution to journalArticlepeer-review

Abstract

There is general agreement that the controlled clinical trial is the best method for analgesic evaluation. Current practice in clinical analgesimetry, however, varies considerably with regard to design, measurement of pain, and statistical analysis. We attempted to assess the degree of this diversity by a questionnaire survey of a sample of investigators who are currently conducting clinical pain studies. To examine how various statistical methods perform in practice, we reanalyzed data from four of our published analgesic studies using a number of standard methods.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalClinical pharmacology and therapeutics
Volume34
Issue number3
DOIs
StatePublished - Sep 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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