Evaluation of community-based serologic screening for identification of chronic Salmonella Typhi carriers in Vietnam

A. Gupta, N. T. My Thanh, S. J. Olsen, S. Sivapalasingam, T. T. My Trinh, N. T. Phuong Lan, R. M. Hoekstra, W. Bibb, N. T. Minh, T. P. Danh, P. D. Cam, E. D. Mintz

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To determine the utility of screening anti-Vi antibodies to detect chronic Salmonella Typhi carriers in an endemic community. Methods: We conducted a community-based serologic survey for anti-Vi antibodies to identify chronic Salmonella Typhi carriers in a typhoid endemic region in Vietnam. Results: We tested sera from 3209 (67.2%) of 4772 eligible adults. The median age was 37 years (range 20-92), 57.3% were female, 4.6% reported a history of typhoid fever and 0.3% reported typhoid vaccination. Anti-Vi antibody titers tested in Vietnam were <1:40 in 2759 (86.0%), 1:40 in 194 (6.0%), 1:80 in 168 (5.2%), 1:160 in 57 (1.8%), and ≥1:320 in 31 (1.0%). On re-testing in the USA, an additional 19 sera with titers ≥1:160 were identified. We collected 589 rectal swabs from 103 (96.3%) of 107 persons with Vi antibody titers ≥1:160 and 183 swabs from 33 persons with antibody titers <1:80. No Salmonella Typhi was isolated. Conclusions: Community-based serologic screening is a feasible, but impractical method for identifying chronic Salmonella Typhi carriers. Background levels of anti-Vi antibody titers in this endemic area may be high despite a low prevalence of chronic carriers.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalInternational Journal of Infectious Diseases
Volume10
Issue number4
DOIs
StatePublished - Jul 2006
Externally publishedYes

Keywords

  • Chronic carrier
  • Community-based
  • Salmonella Typhi
  • Screening
  • Typhoid fever
  • Vietnam

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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