Evaluation of cardiac cone—beam single photon emission computed tomography using observer performance experiments and receiver operating characteristic analysis

Benjamin M.W. Tsui, James A. Terry, Grant T. Gullberg

Research output: Contribution to journalArticlepeer-review

Abstract

RATIONALE AND OBJECTIVES. Single photon emission computed tomography (SPECT) with a cone-beam collimator improves the trade-off between detection efficiency and spatial resolution for cardiac imaging. However, acquisitions using orbits where the focus remains in a plane do not provide sufficient data for exact reconstruction. In the current study the authors evaluate the clinical utility of planar-orbit cone-beam SPECT in detecting a simple myocardial defect. METHODS. Observer performance experiments compared high-resolution cone-beam with same-resolution parallel-hole and fan-beam collimator designs in myocardial defect detection using a computer-simulated cardiac model. The uptake of Thallium-201 in the myocardium and other tissue organs was modeled by a mathematical three-dimensional upper torso phantom from which physically realistic projections were simulated. Eight observers viewed reconstructed transaxial images from the three collimator designs and indicated the certainty with which they detected a Gaussian-shaped defect at a specified location. RESULTS. The area under the receiver operating characteristic curve indicated that the cone-beam design, regardless of slice position, was superior to the fan-beam, which in turn was superior to the parallel-hole design for the specified detection task. conclusions. The observer study demonstrated that reconstruction artifacts resulting from insufficient data sampling do not hinder obtaining improved diagnostic information from planar-orbit cone-beam cardiac SPECT images compared to conventional cardiac SPECT using parallel-hole and fan-beam collimators.

Original languageEnglish (US)
Pages (from-to)1101-1112
Number of pages12
JournalInvestigative radiology
Volume28
Issue number12
DOIs
StatePublished - Dec 1993
Externally publishedYes

Keywords

  • Cardiac
  • Cone-beam
  • Receiver operating characteristic
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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