TY - JOUR
T1 - Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches
AU - Gao, Qiang
AU - Mechin, Ingrid
AU - Kothari, Nayantara
AU - Guo, Zhuyan
AU - Deng, Gejing
AU - Haas, Kimberly
AU - McManus, Jessica
AU - Hoffmann, Dietmar
AU - Wang, Anlai
AU - Wiederschain, Dmitri
AU - Rocnik, Jennifer
AU - Czechtizky, Werngard
AU - Chen, Xin
AU - McLean, Larry
AU - Arlt, Heike
AU - Harper, David
AU - Liu, Feng
AU - Majid, Tahir
AU - Patel, Vinod
AU - Lengauer, Christoph
AU - Garcia-Echeverria, Carlos
AU - Zhang, Bailin
AU - Cheng, Hong
AU - Dorsch, Marion
AU - Huang, Shih Min A
PY - 2013/10/18
Y1 - 2013/10/18
N2 - Background: Little is known about the cancer dependence and druggability of PRP4. Results: Significance of PRP4 catalytic activity is demonstrated, novel substrates are identified, and features of kinase domain structure are revealed. Conclusion: PRP4 is required for cancer cell survival, displays substrate specificity, and is amenable to pharmacological inhibition. Significance: Our results indicate that PRP4 is a potential drug target to pursue in cancer.
AB - Background: Little is known about the cancer dependence and druggability of PRP4. Results: Significance of PRP4 catalytic activity is demonstrated, novel substrates are identified, and features of kinase domain structure are revealed. Conclusion: PRP4 is required for cancer cell survival, displays substrate specificity, and is amenable to pharmacological inhibition. Significance: Our results indicate that PRP4 is a potential drug target to pursue in cancer.
UR - http://www.scopus.com/inward/record.url?scp=84886924772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886924772&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.473348
DO - 10.1074/jbc.M113.473348
M3 - Article
C2 - 24003220
AN - SCOPUS:84886924772
SN - 0021-9258
VL - 288
SP - 30125
EP - 30138
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 42
ER -