Evaluation of aqueductal patency in patients with hydrocephalus: Three-dimensional high-sampling-efficiency technique (SPACE) versus two-dimensional turbo spin echo at 3 tesla

Murat Ucar, Melike Guryildirim, Nil Tokgoz, Koray Kilic, Alp Borcek, Yusuf Oner, Koray Akkan, Turgut Tali

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the accuracy of diagnosing aqueductal patency and image quality between high spatial resolution three-dimensional (3D) high-sampling-efficiency technique (sampling perfection with application optimized contrast using different flip angle evolutions [SPACE]) and T2-weighted (T2W) two-dimensional (2D) turbo spin echo (TSE) at 3-T in patients with hydrocephalus.

Materials and Methods: This retrospective study included 99 patients diagnosed with hydrocephalus. T2W 3D-SPACE was added to the routine sequences which consisted of T2W 2D-TSE, 3D-constructive interference steady state (CISS), and cine phase-contrast MRI (PC-MRI). Two radiologists evaluated independently the patency of cerebral aqueduct and image quality on the T2W 2D-TSE and T2W 3D-SPACE. PC-MRI and 3D-CISS were used as the reference for aqueductal patency and image quality, respectively. Inter-observer agreement was calculated using kappa statistics.

Results: The evaluation of the aqueductal patency by T2W 3D-SPACE and T2W 2D-TSE were in agreement with PC-MRI in 100% (99/99; sensitivity, 100% [83/83]; specificity, 100% [16/16]) and 83.8% (83/99; sensitivity, 100% [67/83]; specificity, 100% [16/16]), respectively (p < 0.001). No significant difference in image quality between T2W 2D-TSE and T2W 3D-SPACE (p = 0.056) occurred. The kappa values for inter-observer agreement were 0.714 for T2W 2D-TSE and 0.899 for T2W 3D-SPACE.

Conclusion: Three-dimensional-SPACE is superior to 2D-TSE for the evaluation of aqueductal patency in hydrocephalus. T2W 3D-SPACE may hold promise as a highly accurate alternative treatment to PC-MRI for the physiological and morphological evaluation of aqueductal patency.

Original languageEnglish (US)
Pages (from-to)827-835
Number of pages9
JournalKorean journal of radiology
Volume15
Issue number6
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • 3D-SPACE
  • Aqueductal patency
  • Cerebrospinal fluid flow
  • Hydrocephalus
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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