Evaluation of abnormal liver tests

Research output: Contribution to journalReview article

Abstract

Serum biochemical tests play an important role in the diagnosis and management of acute and chronic liver disease. Their routine use has led to the increased detection of liver enzyme abnormalities in otherwise asymptomatic patients. These tests consist of markers of hepatocellular injury, tests of liver metabolism, and tests of liver synthetic function. Liver injury can be characterized as primarily hepatocellular versus cholestatic based on the degree of elevation of aminotransferases compared with alkaline phosphatase. A comprehensive history, physical examination, and assessment of pattern of liver injury with additional directed laboratory testing establish the cause of hepatobiliary disease in most cases.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalMedical Clinics of North America
Volume98
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Alkaline phosphatase
  • Aminotransferases
  • Bilirubin metabolism
  • Cholestasis
  • Hepatocellular injury

ASJC Scopus subject areas

  • Medicine(all)

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