Evaluation of abnormal liver tests

Tinsay A. Woreta; Saleh A. Alqahtani

doi:10.1016/j.mcna.2013.09.005

Evaluation of abnormal liver tests

Tinsay A. Woreta, Saleh A. Alqahtani

School of Medicine

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Serum biochemical tests play an important role in the diagnosis and management of acute and chronic liver disease. Their routine use has led to the increased detection of liver enzyme abnormalities in otherwise asymptomatic patients. These tests consist of markers of hepatocellular injury, tests of liver metabolism, and tests of liver synthetic function. Liver injury can be characterized as primarily hepatocellular versus cholestatic based on the degree of elevation of aminotransferases compared with alkaline phosphatase. A comprehensive history, physical examination, and assessment of pattern of liver injury with additional directed laboratory testing establish the cause of hepatobiliary disease in most cases.

Original language	English (US)
Pages (from-to)	1-16
Number of pages	16
Journal	Medical Clinics of North America
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/j.mcna.2013.09.005
State	Published - Jan 2014

Keywords

Alkaline phosphatase
Aminotransferases
Bilirubin metabolism
Cholestasis
Hepatocellular injury

ASJC Scopus subject areas

General Medicine

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10.1016/j.mcna.2013.09.005

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title = "Evaluation of abnormal liver tests",

abstract = "Serum biochemical tests play an important role in the diagnosis and management of acute and chronic liver disease. Their routine use has led to the increased detection of liver enzyme abnormalities in otherwise asymptomatic patients. These tests consist of markers of hepatocellular injury, tests of liver metabolism, and tests of liver synthetic function. Liver injury can be characterized as primarily hepatocellular versus cholestatic based on the degree of elevation of aminotransferases compared with alkaline phosphatase. A comprehensive history, physical examination, and assessment of pattern of liver injury with additional directed laboratory testing establish the cause of hepatobiliary disease in most cases.",

keywords = "Alkaline phosphatase, Aminotransferases, Bilirubin metabolism, Cholestasis, Hepatocellular injury",

author = "Woreta, {Tinsay A.} and Alqahtani, {Saleh A.}",

note = "Funding Information: This work was supported by research grant from HRH Meshal Bin Abdulah Al Saud Foundation.",

year = "2014",

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AU - Woreta, Tinsay A.

AU - Alqahtani, Saleh A.

N1 - Funding Information: This work was supported by research grant from HRH Meshal Bin Abdulah Al Saud Foundation.

PY - 2014/1

Y1 - 2014/1

N2 - Serum biochemical tests play an important role in the diagnosis and management of acute and chronic liver disease. Their routine use has led to the increased detection of liver enzyme abnormalities in otherwise asymptomatic patients. These tests consist of markers of hepatocellular injury, tests of liver metabolism, and tests of liver synthetic function. Liver injury can be characterized as primarily hepatocellular versus cholestatic based on the degree of elevation of aminotransferases compared with alkaline phosphatase. A comprehensive history, physical examination, and assessment of pattern of liver injury with additional directed laboratory testing establish the cause of hepatobiliary disease in most cases.

AB - Serum biochemical tests play an important role in the diagnosis and management of acute and chronic liver disease. Their routine use has led to the increased detection of liver enzyme abnormalities in otherwise asymptomatic patients. These tests consist of markers of hepatocellular injury, tests of liver metabolism, and tests of liver synthetic function. Liver injury can be characterized as primarily hepatocellular versus cholestatic based on the degree of elevation of aminotransferases compared with alkaline phosphatase. A comprehensive history, physical examination, and assessment of pattern of liver injury with additional directed laboratory testing establish the cause of hepatobiliary disease in most cases.

KW - Alkaline phosphatase

KW - Aminotransferases

KW - Bilirubin metabolism

KW - Cholestasis

KW - Hepatocellular injury

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Evaluation of abnormal liver tests

Abstract

Keywords

ASJC Scopus subject areas

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