Evaluation of a novel plasma (1,3)-β-D-glucan detection assay for diagnosis of candidemia in pediatric patients

Ying Liu; Feng Chen; Xiaodong Zhu; Lisong Shen; Sean X. Zhang

doi:10.1128/JCM.00673-15

Evaluation of a novel plasma (1,3)-β-D-glucan detection assay for diagnosis of candidemia in pediatric patients

Ying Liu, Feng Chen, Xiaodong Zhu, Lisong Shen, Sean X. Zhang

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We evaluated a novel plasma (1,3)-β-D-glucan (BDG) detection assay for the diagnosis of candidemia in children. The median BDG levels were 73.4 pg/ml in patients with candidemia and <10 pg/ml in patients without candidemia (P<0.001). Receiver operating characteristic analysis revealed a cutoff point of 14 pg/ml and an area under the curve of 0.802. At these values, the assay demonstrated 68% sensitivity, 91% specificity, 66% positive predictive value, and 91% negative predictive value. Plasma BDG levels were undetectable in 18 candidemia cases.

Original language	English (US)
Pages (from-to)	3017-3020
Number of pages	4
Journal	Journal of clinical microbiology
Volume	53
Issue number	9
DOIs	https://doi.org/10.1128/JCM.00673-15
State	Published - Sep 1 2015

ASJC Scopus subject areas

Microbiology (medical)

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abstract = "We evaluated a novel plasma (1,3)-β-D-glucan (BDG) detection assay for the diagnosis of candidemia in children. The median BDG levels were 73.4 pg/ml in patients with candidemia and <10 pg/ml in patients without candidemia (P<0.001). Receiver operating characteristic analysis revealed a cutoff point of 14 pg/ml and an area under the curve of 0.802. At these values, the assay demonstrated 68% sensitivity, 91% specificity, 66% positive predictive value, and 91% negative predictive value. Plasma BDG levels were undetectable in 18 candidemia cases.",

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AU - Zhang, Sean X.

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Evaluation of a novel plasma (1,3)-β-D-glucan detection assay for diagnosis of candidemia in pediatric patients

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