Evaluation of a new DNA test for detection of carcinogenic human papillomavirus

Philip E. Castle, Erin C. Gutierrez, Sharon V. Leitch, Courtney E. Maus, Ray A. McMillian, William A. Nussbaumer, Laurence M. Vaughan, Cosette M. Wheeler, Patti E. Gravitt, Mark Schiffman

Research output: Contribution to journalArticle

Abstract

Using archived specimens, we evaluated a new automated real-time PCR assay (BD Diagnostics) that detects all carcinogenic human papillomaviruses (HPV) and provides HPV genotyping for seven of them, including HPV16 and HPV18, the two most carcinogenic HPV genotypes. We found comparable results with Hybrid Capture 2 (HC2) for detection of carcinogenic HPV (n = 473) and with Linear Array and Line Blot Assay (n = 371) for detection of individual HPV genotypes.

Original languageEnglish (US)
Pages (from-to)3029-3032
Number of pages4
JournalJournal of clinical microbiology
Volume49
Issue number8
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Microbiology (medical)

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  • Cite this

    Castle, P. E., Gutierrez, E. C., Leitch, S. V., Maus, C. E., McMillian, R. A., Nussbaumer, W. A., Vaughan, L. M., Wheeler, C. M., Gravitt, P. E., & Schiffman, M. (2011). Evaluation of a new DNA test for detection of carcinogenic human papillomavirus. Journal of clinical microbiology, 49(8), 3029-3032. https://doi.org/10.1128/JCM.00422-11