Evaluation of a modified ACR20 scoring system in patients with rheumatoid arthritis receiving treatment with etanercept

J. A. Goldman, H. A. Xia, B. White, H. Paulus

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate a modified American College of Rheumatology 20 (mACR20) scoring system for patients with rheumatoid arthritis. Methods: The data were evaluated from one study on patients with methotreNxate (MTX)-naive early rheumatoid arthritis (ERA) and another study on patients with DMARD-refractory late rheumatoid arthritis (LRA). For mACR20 scoring, acute-phase reactant measurements were excluded, and 20% improvement from baseline was determined by 2 or 3 of the 4 remaining ACR components. Results: For full joint counts with data from patients with ERA, marked differences favoured 25 mg etanercept (ETN) over 10 mg ETN by using the unmodified ACR20 (69% v 55%), the mACR203 of 4 (63% v 49%) and the mACR20 2 of 4 (72% v 58%). An assessment of 28 joints showed similar findings. In the trial on patients with LRA, considerably more patients in both ETN groups achieved a clinical response compared with placebo by using the ACR20, the mACR203 of 4 and the mACR202 of 4, whether using full or 28 joint counts. The mACR203 of 4 and full joint counts with data on patients with ERA showed a marked difference between the MTX and 10 mg ETN groups (63% v 49%), which was not observed with the ACR20. Conclusion: Patterns of improvement indicated by mACR20 scores were consistent with standard ACR20 scores.

Original languageEnglish (US)
Pages (from-to)1649-1652
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume65
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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