Evaluation of a measurement strategy for Parkinson's disease: Assessing patient health-related quality of life

A. M. Damiano, M. M. McGrath, M. K. Willian, C. F. Snyder, P. A. LeWitt, P. F. Reyes, R. R. Richter, E. D. Means

Research output: Contribution to journalArticle

Abstract

This study evaluated the feasibility and psychometric properties of self-completed and telephone interview versions of a patient health-related quality-of-life (HQL) questionnaire for Parkinson's disease that included the SF-36 Health Survey (SF-36), the Parkinson's Disease Questionnaire (PDQ-39), and the Medical Outcomes Study Sexual Function Survey. Parkinson's disease patients (n = 150) completed the questionnaire twice: once at the study site and once over the telephone in a randomized order. Ninety-four percent of enrolled patients completed the first HQL assessment and 88% completed both assessments. Cronbach's α exceeded 0.70 for all scales except for the self-completed PDQ-39 Social Support subscale (0.57) and the telephone interview PDQ-39 Social Support (0.60) and Cognitions (0.67) subscales and the SF-36 General Health (0.60) and Social Function (0.61) subscales. There were no statistically significant differences in mean HQL scale scores across the two modes of administration. Mean scores for 3 of the PDQ-39 subscales and the Summary Index were significantly poorer (p < 0.05) for patients at later clinical stages. Similarly, patients with dyskinesias reported significantly poorer scores for 4 of the PDQ-39 subscales and the Summary Index and patients with self-reported comorbidities reported poorer SF-36 Physical Function and General Health subscale scores than patients without dyskinesias and comorbidities, respectively. This study suggests that the self-completed and telephone interview versions of the patient HQL questionnaire are feasible and valid for future clinical trial applications.

Original languageEnglish (US)
Pages (from-to)87-100
Number of pages14
JournalQuality of Life Research
Volume9
Issue number1
DOIs
StatePublished - Sep 14 2000
Externally publishedYes

Keywords

  • Health status
  • Mode of administration
  • Parkinson's disease
  • Psychometrics
  • Quality of life

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Damiano, A. M., McGrath, M. M., Willian, M. K., Snyder, C. F., LeWitt, P. A., Reyes, P. F., Richter, R. R., & Means, E. D. (2000). Evaluation of a measurement strategy for Parkinson's disease: Assessing patient health-related quality of life. Quality of Life Research, 9(1), 87-100. https://doi.org/10.1023/A:1008928321652