Evaluation of a live-attenuated human parainfluenza type 1 vaccine in adults and children

Ruth A. Karron; Jocelyn San Mateo; Bhagvanji Thumar; Anne Schaap-Nutt; Ursula J. Buchholz; Alexander C. Schmidt; Emmalene J. Bartlett; Brian R. Murphy; Peter L. Collins

doi:10.1093/jpids/piu104

Evaluation of a live-attenuated human parainfluenza type 1 vaccine in adults and children

Ruth A. Karron, Jocelyn San Mateo, Bhagvanji Thumar, Anne Schaap-Nutt, Ursula J. Buchholz, Alexander C. Schmidt, Emmalene J. Bartlett, Brian R. Murphy, Peter L. Collins

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: Adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1-seronegative children.

Original language	English (US)
Pages (from-to)	e143-e146
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	4
Issue number	4
DOIs	https://doi.org/10.1093/jpids/piu104
State	Published - Dec 1 2015

Keywords

Children
HPIV-1 vaccine
Lower respiratory tract illness

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases

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10.1093/jpids/piu104

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abstract = "We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: Adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1-seronegative children.",

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AU - Thumar, Bhagvanji

AU - Schaap-Nutt, Anne

AU - Buchholz, Ursula J.

AU - Schmidt, Alexander C.

AU - Bartlett, Emmalene J.

AU - Murphy, Brian R.

AU - Collins, Peter L.

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Evaluation of a live-attenuated human parainfluenza type 1 vaccine in adults and children

Abstract

Keywords

ASJC Scopus subject areas

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