Evaluation of a live attenuated human metapneumovirus vaccine in adults and children

Ruth A. Karron, Jocelyn San Mateo, Kimberli Wanionek, Peter L. Collins, Ursula J. Buchholz

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population for vaccination. rHMPV-Pa was appropriately restricted in replication in adults and HMPV-seropositive children but wasoverattenuated for HMPV-seronegative children.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalJournal of the Pediatric Infectious Diseases Society
Volume7
Issue number1
DOIs
StatePublished - Feb 19 2018

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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