Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions

Rebecca L. Klein, Julie A. Mook, David M Euhus, Roshni Rao, Ralph T. Wynn, Amy B. Eastman, A. Marilyn Leitch

Research output: Contribution to journalArticle

Abstract

Background and Objectives HydroMARK® is a newly available biopsy marker for image-guided needle biopsies of non-palpable breast lesions. Objective was to determine if the marker could be utilized independently for lesion localization using intra-operative ultrasound alone. Methods A single institution retrospective review identified patients who underwent surgical excision of breast lesions after placement of the HydroMARK®. Endpoints included intra-operative visualization of the marker, successful excision of the lesion, and presence of the marker on specimen radiograph. Results The study included 31 lesions in 25 patients. Twenty-nine (93.6%) HydroMARKSs® were adequately visualized by intra-operative ultrasound. Intra-operative ultrasound without pre-operative placement of a localizing device was successful for localization in six cases (19.4%). Intra-operative difficulties were encountered in 16 of 31 (51.6%) procedures. This included either extrusion of the marker when the biopsy tract was transected in 14 (45.2%) cases or migration of the marker prior to the procedure in two (6.4%) cases. The marker was visualized on specimen radiograph in 15 (48.4%) cases. Conclusions While intraoperative sonographic visibility was excellent, a large number of excisions were associated with extrusion of the marker. Modifications are needed to improve acceptability of this marker for intra-operative localization independent of pre-operative wire or seed localization. J. Surg. Oncol. 2012; 105:591-594.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalJournal of Surgical Oncology
Volume105
Issue number6
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Hydrogel
Seeds
Breast
Biopsy
Image-Guided Biopsy
Needle Biopsy
Equipment and Supplies

Keywords

  • breast surgery
  • preoperative localization
  • ultrasound

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions. / Klein, Rebecca L.; Mook, Julie A.; Euhus, David M; Rao, Roshni; Wynn, Ralph T.; Eastman, Amy B.; Leitch, A. Marilyn.

In: Journal of Surgical Oncology, Vol. 105, No. 6, 05.2012, p. 591-594.

Research output: Contribution to journalArticle

Klein, Rebecca L. ; Mook, Julie A. ; Euhus, David M ; Rao, Roshni ; Wynn, Ralph T. ; Eastman, Amy B. ; Leitch, A. Marilyn. / Evaluation of a hydrogel based breast biopsy marker (HydroMARK®) as an alternative to wire and radioactive seed localization for non-palpable breast lesions. In: Journal of Surgical Oncology. 2012 ; Vol. 105, No. 6. pp. 591-594.
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abstract = "Background and Objectives HydroMARK{\circledR} is a newly available biopsy marker for image-guided needle biopsies of non-palpable breast lesions. Objective was to determine if the marker could be utilized independently for lesion localization using intra-operative ultrasound alone. Methods A single institution retrospective review identified patients who underwent surgical excision of breast lesions after placement of the HydroMARK{\circledR}. Endpoints included intra-operative visualization of the marker, successful excision of the lesion, and presence of the marker on specimen radiograph. Results The study included 31 lesions in 25 patients. Twenty-nine (93.6{\%}) HydroMARKSs{\circledR} were adequately visualized by intra-operative ultrasound. Intra-operative ultrasound without pre-operative placement of a localizing device was successful for localization in six cases (19.4{\%}). Intra-operative difficulties were encountered in 16 of 31 (51.6{\%}) procedures. This included either extrusion of the marker when the biopsy tract was transected in 14 (45.2{\%}) cases or migration of the marker prior to the procedure in two (6.4{\%}) cases. The marker was visualized on specimen radiograph in 15 (48.4{\%}) cases. Conclusions While intraoperative sonographic visibility was excellent, a large number of excisions were associated with extrusion of the marker. Modifications are needed to improve acceptability of this marker for intra-operative localization independent of pre-operative wire or seed localization. J. Surg. Oncol. 2012; 105:591-594.",
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