Evaluation of a clinical case definition of AIDS in African children

R. I. Colebunders, A. Greenberg, P. Nguyen-Dinh, H. Francis, N. Kabote, L. Izaley, F. Davachi, T. C. Quinn, P. Piot

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


In July 1986, a provisional clinical case definition of AIDS in children, developed by the World Health Organization (WHO) for surveillance purposes in Africa, was tested on 159 patients hospitalized in the Department of Pediatrics at Mama Yemo Hospital, Kinshasa, Zaire. Twenty-one (13%) of these children were seropositive for HIV. In this population, the clinical case definition of pediatric AIDS was found to be fairly specific (87%) but lacked sensitivity (35%). The positive predictive value for HIV seropositivity was 25%. This study suggests that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited.

Original languageEnglish (US)
Pages (from-to)151-153
Number of pages3
Issue number3
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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