Evaluation of 70–150-μm doxorubicin-eluting beads for transcatheter arterial chemoembolization in the rabbit liver VX2 tumour model

Ali Gholamrezanezhad, Sahar Mirpour, Jean Francois H. Geschwind, Pramod Rao, Romaric Loffroy, Olivier Pellerin, Eleni A. Liapi

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the pharmacokinetic profile (PK) and embolization effect of 70–150-μm doxorubicin eluting beads (DEBs) following intra-arterial injection (i.a.) in the rabbit liver VX2 tumour model. Materials and methods: In this ACUC-approved study, 25 white New Zealand rabbits were randomly assigned into a small DEB group (SDB, n = 7, 70–150-μm DEBs), large DEB group (LDB, n = 7, 100–300-μm DEBs), untreated controls (n = 7), and doxorubicin controls (n = 4, without tumour, received i.a. 12.5 mg doxorubicin). Plasma PK was assessed up to 180 min post-injection. Drug tissue and liver enzyme levels, radiologic tumor response and histopathologic tumour necrosis were assessed at 7 days. Results: Mean tumour doxorubicin concentrations were 922.83 nM (SD = 722.05) and 361.48 nM (SD = 473.23) for the SDB and LDB, respectively (p = 0.005). There was no statistically significant difference in tumour doxorubicinol, plasma doxorubicin and doxorubicinol PK values. More beads were observed in the SDB tumours (p = 0.01). Liver enzymes increased and gradually declined over the observation period, with significantly higher values in the SDB. Conclusion: In this preclinical study, plasma PK of i.a.-injected 70–150-μm DEBs was not different than that of 100–300-μm DEBs. More beads and higher tissue doxorubicin levels were observed in the SDB tumours. Key Points: • Small and large doxorubicin-eluting beads show similar plasma pharmacokinetic profiles. • Higher tissue doxorubicin levels were observed in the small bead group. • Liver enzymes were overall significantly higher in the small bead group.

Original languageEnglish (US)
Pages (from-to)3474-3482
Number of pages9
JournalEuropean radiology
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Doxorubicin
  • Drug-eluting beads, DEBs
  • Injections, intra-arterial
  • Liver neoplasms
  • Microspheres

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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