TY - JOUR
T1 - Evaluation of 500- and 1,000-mg doses of ciprofloxacin for the treatment of chancroid
AU - Bodhidatta, L.
AU - Taylor, D. N.
AU - Chitwarakorn, A.
AU - Kuvanont, K.
AU - Echeverria, P.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg) 500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 μg/ml (range, 0.002 to 0.03 μg/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.
AB - A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg) 500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 μg/ml (range, 0.002 to 0.03 μg/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.
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U2 - 10.1128/AAC.32.5.723
DO - 10.1128/AAC.32.5.723
M3 - Article
C2 - 3293526
AN - SCOPUS:0023895078
SN - 0066-4804
VL - 32
SP - 723
EP - 725
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 5
ER -