A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg) 500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 μg/ml (range, 0.002 to 0.03 μg/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.
|Original language||English (US)|
|Number of pages||3|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Pharmacology (medical)