Evaluation of 500- and 1,000-mg doses of ciprofloxacin for the treatment of chancroid

L. Bodhidatta, D. N. Taylor, A. Chitwarakorn, K. Kuvanont, P. Echeverria

Research output: Contribution to journalArticlepeer-review

Abstract

A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg) 500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 μg/ml (range, 0.002 to 0.03 μg/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.

Original languageEnglish (US)
Pages (from-to)723-725
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume32
Issue number5
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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