Evaluating the Role of Interdigitated Neoadjuvant Chemotherapy and Radiation in the Management of High-Grade Soft-Tissue Sarcoma: The Johns Hopkins Experience

Raju R. Raval, Deborah Frassica, Katherine Thornton, Christian Meyer, David S. Ettinger, Frank Frassica, Kristin Weber, Stephanie A. Terezakis

Research output: Contribution to journalArticle

Abstract

Objectives: High-grade soft-tissue sarcoma (STS) has a poor prognosis. The goal of this study was to review treatment outcomes of patients with high-grade STS treated with interdigitated neoadjuvant chemotherapy (CT) and radiation at our institution. Materials and Methods: Patients with high-grade STS (1997 to 2010) were planned for treatment with 3 cycles of neoadjuvant CT, interdigitated preoperative radiation therapy (44 Gy administered in split courses with a potential 16 Gy postoperative boost), and 3 cycles of postoperative CT. Cancer control outcomes at 3 years were analyzed. Results: Sixteen patients with high-grade STS were evaluated. Median age was 53 years, the median longest tumor diameter was 14.6 cm, and median follow-up was 33 months. All 16 patients received 2 or 3 cycles of neoadjuvant CT and all patients completed neoadjuvant RT. The estimated 3-year rate for local control was 100%, disease-free survival 62.5%, and overall survival 73.4%. Conclusions: Patients with high-grade STS treated with interdigitated neoadjuvant CT and radiation before surgical resection had excellent rates of local control, along with disease-free survival and overall survival similar to previously published reports. This combined-modality approach continues to have a role in the treatment of patients with high-grade STS.

Original languageEnglish (US)
Pages (from-to)214-217
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume40
Issue number2
DOIs
StatePublished - 2017

Keywords

  • interdigitated
  • neoadjuvant
  • sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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