Evaluating the efficacy of bronchoscopy for the diagnosis of early stage lung cancer

David M. DiBardino, Anil Vachani, Lonny Yarmus

Research output: Contribution to journalReview articlepeer-review


Novel diagnostic techniques for lung cancer are rapidly evolving. Specifically, several novel changes to bronchoscopy are reaching clinical evaluation. It is critical to think about historical standards for evaluating new diagnostic testing, and put those concepts into the framework of lung cancer. Often a thorough evaluation of new technology is not performed as a part of regulatory marketing clearance. Therefore, we must consider how to best study novel testing beyond these regulatory minimums. There are several methodological principles that can achieve this goal such as using a control arm, more thorough reporting of enrolled patients, consecutive patient enrollment, and adequate sample size. We hope clinicians, particularly those performing bronchoscopy for lung nodules, will feel empowered to critically appraise the evaluation of new diagnostic testing for lung cancer moving forward.

Original languageEnglish (US)
Pages (from-to)3245-3252
Number of pages8
JournalJournal of Thoracic Disease
Issue number6
StatePublished - Jun 1 2020


  • Bronchoscopy
  • Lung cancer
  • Lung nodule

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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