Evaluating new treatments for anaplastic thyroid cancer

Andrés Coca-Pelaz, Juan P. Rodrigo, Fernando Lopez, Jatin P. Shah, Carl E. Silver, Abir Al Ghuzlan, C. Willemien Menke-van der Houven van Oordt, Robert C. Smallridge, Ashok R. Shaha, Peter Angelos, William M. Mendenhall, Cesare Piazza, Kerry D. Olsen, June Corry, Ralph P. Tufano, Alvaro Sanabria, Sandra Nuyts, Cherie Ann Nathan, Vincent Vander Poorten, Fernando Luiz DiasCarlos Suarez, Nabil F. Saba, Pim de Graaf, Michelle D. Williams, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review


Introduction: Anaplastic thyroid cancer (ATC) is one of the most lethal diseases known to humans with a median survival of 5 months. The American Thyroid Association (ATA) recently published guidelines for the treatment of this dreadful thyroid malignancy. Areas covered: This review presents the current therapeutic landscape of this challenging disease. We also present the results from trials published over the last five years and summarize currently active clinical trials. Expert opinion: Recent attempts to improve the prognosis of these tumors are moving toward personalized medicine, basing the treatment decision on the specific genetic profile of the individual tumor. The positive results of dabrafenib and trametinib for ATC harboring the BRAF V600E mutation have provided a useful treatment option. For the other genetic profiles, different drugs are available and can be used to individualize the treatment, likely using drug combinations. Combinations of drugs act on different molecular pathways and achieve inhibition at separate areas. With new targeted therapies, average survival has improved considerably and death from local disease progression or airway compromise is less likely with improvement in quality of life. Unfortunately, the results remain poor in terms of survival.

Original languageEnglish (US)
Pages (from-to)1239-1247
Number of pages9
JournalExpert Review of Anticancer Therapy
Issue number11
StatePublished - 2022
Externally publishedYes


  • Anaplastic thyroid cancer
  • Tyrosine-kinase inhibitors
  • immune checkpoint inhibitors
  • immunotherapy
  • targeted therapy
  • treatment

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


Dive into the research topics of 'Evaluating new treatments for anaplastic thyroid cancer'. Together they form a unique fingerprint.

Cite this