Evaluating mutant mice: Anatomic pathology

C. Brayton, M. Justice, C. A. Montgomery

Research output: Contribution to journalArticlepeer-review

Abstract

As the human and mouse genome projects approach their goals, initiatives in functional genomics are advancing. When the nucleotide sequences are available, identification of gene functions will assume even greater importance. Determination of gene products and their proximal biochemical functions provide a part of the picture, but determination of their functions in the context of the whole organism is the ultimate goal. The manipulated mouse genome has become accepted as a model for understanding the genetic basis of human conditions and diseases. Consequently, biomedical research institutions have seen significant increases in the use of mice since the early 1980s, and these increases are largely attributable to the use of genetically modified mice. The role of comparative pathology in research on mutant mouse models of disease is increasing in response to these trends. Evaluation and phenotypic characterization of mutant mice, via clinical and anatomic pathology techniques, will be an important component of functional genomics initiatives.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalVeterinary pathology
Volume38
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Anatomy
  • Histology
  • Inbred mice
  • Knockout mice
  • Mutants
  • Pathology
  • Transgenics

ASJC Scopus subject areas

  • veterinary(all)

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