Evaluating Cognitive Reserve Through the Prism of Preclinical Alzheimer Disease

Anja Soldan; Corinne Pettigrew; Marilyn Albert

doi:10.1016/j.psc.2017.10.006

Evaluating Cognitive Reserve Through the Prism of Preclinical Alzheimer Disease

Anja Soldan, Corinne Pettigrew, Marilyn Albert

School of Medicine

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The concept of cognitive reserve (CR) was proposed to account for the discrepancy between levels of brain pathologic features or damage and clinical and cognitive function. This article provides a detailed review of prospective longitudinal studies that have investigated the interaction between CR and Alzheimer's disease (AD) biomarkers on clinical and cognitive outcomes among individuals with preclinical AD. Current evidence shows that higher levels of CR are associated with a delay in the onset of symptoms of mild cognitive impairment and that there may be multiple pathways by which CR exerts its protective effects.

Original language	English (US)
Pages (from-to)	65-77
Number of pages	13
Journal	Psychiatric Clinics of North America
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.psc.2017.10.006
State	Published - Mar 2018

Keywords

Alzheimer disease
Amyloid
Atrophy
Biomarkers
Cognitive reserve
Mild cognitive impairment
Tau

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1016/j.psc.2017.10.006

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keywords = "Alzheimer disease, Amyloid, Atrophy, Biomarkers, Cognitive reserve, Mild cognitive impairment, Tau",

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Evaluating Cognitive Reserve Through the Prism of Preclinical Alzheimer Disease

Abstract

Keywords

ASJC Scopus subject areas

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