Evaluating Cognitive Reserve Through the Prism of Preclinical Alzheimer Disease

Research output: Contribution to journalReview articlepeer-review


The concept of cognitive reserve (CR) was proposed to account for the discrepancy between levels of brain pathologic features or damage and clinical and cognitive function. This article provides a detailed review of prospective longitudinal studies that have investigated the interaction between CR and Alzheimer's disease (AD) biomarkers on clinical and cognitive outcomes among individuals with preclinical AD. Current evidence shows that higher levels of CR are associated with a delay in the onset of symptoms of mild cognitive impairment and that there may be multiple pathways by which CR exerts its protective effects.

Original languageEnglish (US)
Pages (from-to)65-77
Number of pages13
JournalPsychiatric Clinics of North America
Issue number1
StatePublished - Mar 2018


  • Alzheimer disease
  • Amyloid
  • Atrophy
  • Biomarkers
  • Cognitive reserve
  • Mild cognitive impairment
  • Tau

ASJC Scopus subject areas

  • Psychiatry and Mental health

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